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Colorectal cancer is the third most common cancer and the fourth leading cause of death from cancer worldwide. This study provides an overview of changes in sociod-demographic parameters in patients with colorectal cancer (henceforth CRC) disease in a local cancer hospital in Sulaymaniyah province of Kurdistan region of Iraq. The study included 113 patients admitted to Hiwa Cancer Hospital, Sulaymaniyah from January 2014 to December 2015. The data collection lasted for 3 weeks (from 19/12/2015 to 11/01/2016) and was obtained from the management department of Hiwa Cancer Hospital. Several socio-demographic parameters including age, gender, and smoking, as well as biochemical parameters such as liver function, renal function and blood glucose level were studied and statistically analyzed. Results have shown that the majority of CRC patients were neither current smoker nor x-smoker (P-value < 0.05). Males suffered from CRC at an earlier age compared to females (P-value < 0.05). Regarding the biochemical tests, there was no significant correlation between CRC and impaired liver function during the diagnosis process and most of the study patients had a normal liver function test on presentation. In contrast, the correlation between CRC and impaired renal function on presentation was statistically siginificant (P-value < 0.05). No significant difference was noted in the means of hematological and biochemical parameters between males and females, except for white blood cells and serum Aspartate Aminotransferase. White blood cells and total serum bilirubin showed significant differences (P-value < 0.05) between smoker and nonsmoker sub-populations. It was concluded that CRC is one of the common cancers in Sulaymaniyah province. Males develop it at an earlier age compared to females, and the impaired renal function is a significant finding on presentation.
Bond, J. H.,(2000). Polyp guideline: diagnosis, treatment, and surveillance for patients with colorectal polyps. The American journal of gastroenterology, 95(11), 3053-3063.
Clark, J. C., Collan, Y., Eide, T. J., Estève, J., Ewen, S., Gibbs, N. M. et al., (1985). Prevalence of polyps in an autopsy series from areas with varying incidence of large‐bowel cancer. International journal of cancer, 36(2), 179-186.
Cook, S. N., Giddings, B., Parikh-Patel, A., Kizer, K. W., Kwong, S., Bates, J., & Snipes, K. (2013). Cancer in California, 1988–2009. Report.
Edwards, B. K., Ward, E., Kohler, B. A., Eheman, C., Zauber, A. G., Anderson, R. N. et al., (2010). Annual report to the nation on the status of cancer, 1975‐2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer, 116(3), 544-573.
Hannan, L. M., Jacobs, E. J., & Thun, M. J. (2009). The association between cigarette smoking and risk of colorectal cancer in a large prospective cohort from the United States. Cancer Epidemiol Biomarkers Prev, 18(12), 3362-3367. doi:10.1158/1055-9965.epi-09-0661
Holt, P. R., Kozuch, P., & Mewar, S. (2009). Colon cancer and the elderly: from screening to treatment in management of GI disease in the elderly. Best Practice & Research Clinical Gastroenterology, 23(6), 889-907.
Lee, I. M., Shiroma, E. J., Lobelo, F., Puska, P., Blair, S. N., & Katzmarzyk, P. T. (2012). Impact of Physical Inactivity on the World’s Major Non-Communicable Diseases. Lancet, 380(9838), 219-229. doi:10.1016/s0140-6736(12)61031-9
Lee, Y.-J., Lee, H.-R., Nam, C.-M., Hwang, U.-K., & Jee, S.-H. (2006). White blood cell count and the risk of colon cancer. Yonsei medical journal, 47(5), 646-656.
Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans et al., (2012). Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 380(9859), 2095-2128. doi:10.1016/s0140-6736(12)61728-0
Miller, A. B., Chamberlain, J., Day, N., Hakama, M., & Prorok, P. (1990). Report on a workshop of the UICC project on evaluation of screening for cancer. International journal of cancer, 46(5), 761-769.
Molanaie, N., Rahimi, E., & Aiobi, S. (2000). Epidemialogy of Colorectal Cancer in Kurdistan province during 1995-1999. Scientific Journal of Kurdistan University of Medical Sciences, 5(1), 22-25.
Nelson, J., Rinard, K., Haynes, A., Filleur, S., & Nelius, T. (2011). Extraluminal colonic carcinoma invading into kidney: A case report and review of the literature. ISRN urology, 2011.
Ono, T., Uehara, Y., Saito, Y., & Ikehata, H. (2002). Mutation theory of aging, assessed in transgenic mice and knockout mice. Mechanisms of ageing and development, 123(12), 1543-1552.
Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55(2), 74-108.
Prizment, A. E., Anderson, K. E., Visvanathan, K., & Folsom, A. R. (2011). Association of inflammatory markers with colorectal cancer incidence in the atherosclerosis risk in communities study. Cancer Epidemiology Biomarkers & Prevention, 20(2), 297-307.
Rasouli, M. A., Moradi, G., Roshani, D., Nikkhoo, B., Ghaderi, E., & Ghaytasi, B. (2017). Prognostic factors and survival of colorectal cancer in Kurdistan province, Iran: A population-based study (2009–2014). Medicine, 96(6).
Rex, D. K., Johnson, D. A., Anderson, J. C., Schoenfeld, P. S., Burke, C. A., & Inadomi, J. M. (2009). American College of Gastroenterology guidelines for colorectal cancer screening 2008. The American journal of gastroenterology, 104(3), 739.
Roncucci, L., Ponz de Leon, M., Scalmati, A., Malagoli, G., Pratissoli, S., Perini, M., & Chahin, N. J. (1988). The influence of age on colonic epithelial cell proliferation. Cancer, 62(11), 2373-2377.
Roy, H. K., & Bianchi, L. K. (2009). Differences in colon adenomas and carcinomas among women and men: potential clinical implications. Jama, 302(15), 1696-1697.
Scheele, J. (1993). Hepatectomy for liver metastases. Br J Surg, 80(3), 274-276.
Sinclair, D. A. (2005). Toward a unified theory of caloric restriction and longevity regulation. Mechanisms of ageing and development, 126(9), 987-1002.
Society, A. C. (2008). Cancer facts & figures: The Society.
Taylor, R. W., Barron, M. J., Borthwick, G. M., Gospel, A., Chinnery, P. F., Samuels et al., (2003). Mitochondrial DNA mutations in human colonic crypt stem cells. The Journal of clinical investigation, 112(9), 1351-1360.
Velciov, S., Hoinoiu, B., Hoinoiu, T., Popescu, A., Gluhovschi, C., Gradinaru et al., (2013). Aspects of renal function in patients with colorectal cancer in a gastroenterology clinic of a county hospital in Western Romania. Rom J Intern Med, 51(3-4), 164-171.
Wanebo, H. J., Semoglou, C., Attiyeh, F., & Stearns, M. J. (1978). Surgical management of patients with primary operable colorectal cancer and synchronous liver metastases. The American journal of surgery, 135(1), 81-85.
Watson, A. J., & Collins, P. D. (2011). Colon cancer: a civilization disorder. Dig Dis, 29(2), 222-228. doi:10.1159/000323926
Welch, J., & Donaldson, G. (1979). The clinical correlation of an autopsy study of recurrent colorectal cancer. Annals of surgery, 189(4), 496. Kochar