TY - JOUR AU - Hassan, Sangar A. AU - Abdullah, Media N. AU - Aziz, Dara M. PY - 2021/09/30 Y2 - 2024/03/29 TI - Synthesis of New Series Bis-3-Chloro-β-Lactam Derivatives from Symmetrical Bis-Schiff Bases as Effective Antimicrobial Agents with Molecular Docking Studies JF - Science Journal of University of Zakho JA - SJUOZ VL - 9 IS - 3 SE - DO - 10.25271/sjuoz.2021.9.3.830 UR - https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/830 SP - 128-137 AB - <p class="Abstracttext">Endeavoring to find a new type of antimicrobial agents, a new sequence of bis-Schiff bases and bis-3-cholro-<em>β</em>-lactams are synthesized. An astonishing class of strained compounds is part of the symmetrical bis-Schiff bases that has widespread applications and building blocks for the combination of bis-3-cholro-<em>β</em>-lactams antibiotics. Bis-3-cholro-<em>β</em>-lactams are synthesized through (Staudinger) [2+2] ketene-imine cycloaddition reaction. Structures of the produced compounds are deduced by <sup>1</sup>H, <sup>13</sup>C-NMR, and FT-IR spectroscopies. All produced compounds are shown moderate to good antimicrobial activity compared to human pathogenic bacteria strains (<em>Escherichia coli </em>and<em> Staphylococcus aureus</em>), also compared to <em>Aspergillus Niger </em>and <em>Trichophyton mentagrophytes </em>fungi through the broth microdilution technique. A molecular docking study is used for showing the active sides and binding affinity of the products with the target proteins or receptors of <em>E. coli </em>(PDB ID: 3GI9).</p> ER -