TY - JOUR AU - Zefenkey, Zean PY - 2022/03/14 Y2 - 2024/03/29 TI - Influence of Helicobacter pylori Infection on Atherosclerosis Risk Factors in Older People JF - Science Journal of University of Zakho JA - SJUOZ VL - 10 IS - 1 SE - DO - 10.25271/sjuoz.2022.10.1.884 UR - https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/884 SP - 24-28 AB - <p class="Default"><span lang="EN-US">Atherosclerosis is a significant cause of mortality from cardiovascular disease. The role of <em>Helicobacter pylori</em> <em>(H. pylori</em>) infection in atherogenesis is debatable. The current study aimed to assess the association between <em>H. pylori</em> infection and some risk factors of atherosclerosis in older people. 180 males and females, apparently healthy, over 60 years old, were examined by Fecal Helicobacter Pylori-Antigen ELISA test for <em>H. pylori</em> infection. Blood pressure, high-density lipoprotein-cholesterol (HDL-cholesterol), low-density lipoprotein-cholesterol (LDL-cholesterol), triglyceride (TG), fasting blood glucose, and body mass index (BMI) were measured for all participants.</span></p><p class="Default"><span lang="EN-US">The faecal <em>H. pylori</em> antigen-positive group had a lower HDL-cholesterol level and higher levels of LDL-cholesterol, triglyceride, fasting blood glucose, and BMI than the faecal <em>H. pylori</em> antigen-negative group with a statistical difference (P &lt; 0.05). The faecal <em>H. pylori</em> antigen-positive group had 2.4, 2.2, 2.6, 2.5 fold more likely to have increasing in the LDL-cholesterol, triglyceride, BMI, and decreasing in HDL-cholesterol, respectively. This risk became more considerable after adjustment for gender, age, blood pressure, and fasting blood glucose (adjusted odds ratio (AOR)= 3.1, 3.0, 3.3, 3.3), respectively.</span></p><p class="Default"><span lang="EN-US">The infection by <em>H. pylori</em> in older adults is an independent factor for increasing lipid profile and BMI, which are the key modifying factors for the progress of atherosclerosis.</span></p> ER -