• Jihad Haji Mohammed Dept. of Chemistry, Faculty of Science, University of Soran, Kurdistan Region, Iraq
  • Nabaz Abdulmajeed Mohammad Salih Dept. of Chemistry, Faculty of Science, University of Soran, Kurdistan Region, Iraq



Phenylhydroxylamines, Nitro Compound Derivatives, Electron Withdrawing Groups, Electron Donating Groups Biological active compounds


Synthetic approached towards the synthesis of some novel nitrones derivatives have been started with reduction of nitrobenzene derivatives as starting material bearing electron withdrawing and electron donating groups to corresponding phenylhydroxylamine in presence of zinc dust as reducing agent in aqueous solution of ammonium chloride (NH4Cl). The prepared phenylhydroxylamine derivatives were reacted with different substituted benzaldehydes to give the target derivatives of nitrone. The structures of the synthesized nitrones were characterized by spectroscopic methods FT-IR, 1H-NMR and 13C NMR. Finally, the newly synthesized compounds were screened for their microorganism activities at different concentration, and inhibited growth of Escherichia coli (E. coli) Gram negative, Staphylococcus aureus (S. aureus) Gram positive, and fungi (candida albicans).



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How to Cite

Jihad Haji Mohammed, & Nabaz Abdulmajeed Mohammad Salih. (2023). SYNTHESIS AND CHARACTERIZATION OF SOME NEW NITRONES DERIVATIVES AND SCREENING THEIR BIOLOGICAL ACTIVITIES. Science Journal of University of Zakho, 11(2), 160–169.



Science Journal of University of Zakho