INFLUENCE OF METOCLOPRAMIDE AND 6-GINGEROL ON GASTRIC EMPTYING AND METABOLIC PARAMETERS IN A RAT MODEL OF DIABETIC GASTROPARESIS
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Diabetic Gastroparesis, Metoclopramide, 6-Gingerol, Gastric Emptying, Streptozotocin
Abstract
Diabetic gastroparesis is a neuromuscular condition decelerating gastric motility and gastric emptying in diabetic patients, and it is a condition that is linked to diabetic peripheral neuropathy. Metoclopramide is the only food and drug administration-approved prokinetic agent that treats delayed gastric emptying in diabetic gastroparesis, but it has negative side effects which have made clinicians mention pausing, taking it after four weeks. Zingiber officinale, or Ginger, is a spice that has been traditionally used like a prokinetic agent. 6-gingerol as the main bioactive compound of ginger could have this prokinetic potential of gingerol. Studies investigated the ability of 6 gingerol to improve gastric emptying in diabetic gastroparesis rats, in comparison with metoclopramide. Streptozotocin (40 mg/kg, intraperitoneal injection) injected in male rats to induce diabetes, then fed high-fat high-sugar chow for four weeks to persuade gastroparesis in them. After three weeks of streptozotocin injection, the sample rats were divided into four groups: diabetic gastroparesis, diabetic gastroparesis rats injected with metoclopramide, diabetic gastroparesis rats gavaged with 6-gingerol, and finally a normal control group. Fasting blood glucose, gastric emptying, body weight and relative organ weight, food and water intake, some biochemical parameters, and glutathione peroxidase level by ELISA kit were assessed in this experiment. Diabetic gastroparesis disrupted all of parameters. Metoclopramide and 6-gingerol had improved fasting blood glucose, gastric emptying, food intake, low-density lipoprotein, total cholesterol, and glutathione peroxidase level. The 6-gingerol specifically improved kidney function parameters. Our study concluded that the 6-gingerol might be taken as an alternative to metoclopramide, but further studies should be conducted to determine its mechanism and confirm its clinical usage and applicability.
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References
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