Lipid Profile and Hematological Changes in Gallstone Patients
Keywords:
Gallstone, Lipid profile, Hematological parametersAbstract
The current study was aimed to find out the possible alterations of the serum lipid profile and some hematological parameters in 17 (11 female and 6 male) gall stone former patients with age range between (19-57) years. During this study, total serum cholesterol, triglycerides, lipoproteins (HDL and LDL) and total leukocyte count, erythrocyte count, hemoglobin ratio and platelet count were included. All cases were newly diagnosed in surgery unit of Rizgary hospital in Erbil city. The results showed an elevation in the level of cholesterol, triglyceride and LDL and decreased cholesterol-HDL level in patients with cholelithiasis. Furthermore, the total erythrocyte number, total leukocyte number and platelet count were increased with a significant decrease of blood haemoglobin levels in the gallstone patients. In conclusion the changes in the levels of lipid profile and hematological parameters may be used as markers for gallstone formation.
References
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Crema, E., Ribeiro, E. N., Hial, A. M., Alves-Júnior, J. T., Pastore, R. and Silva, A. A., (2005). Evaluation of the response of cortisol, corticotropin and blood platelets kinetics after laparoscopic and open cholecystectomy. Acta Cir Bras, 20:364-367.
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Habib, L., Mirza, M. R., Channa, M. A., Wasty, W. H., (2009). Role of the liver function tests in symptomatic cholelithiasis. J Ayub Med Coll Abbottabad, 21: 117-119.
Jaraari, A. M., Jagannadharar, P., Patel, T. N., Hai, A., Awamy, H. A., El-Saeity, S. O., Abdel Kafi, E. B., El-Hemri, M N., and Tayesh, M. F., (2010). Quantitative analysis of gallstones in Libyan patients. Libyan J Med, 5: 4627-4631.
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Kim, Y. C., Park, M., Chung, Y. E., Lim, J. S., Kim, M. J. and Kim, K. W., (2007). Gallstone spillage caused by spontaneously perforated hemorrhagic cholecystitis. World J Gastroenterol, 13: 5525-5526.
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Olokoba, A. B., Bojuwoye, B. J., Olokoba, l. b., Braimoh, K. T., Inikori, A. K., and Abdulkareem, A. A., (2009). Relationship between gallstone disease and liver enzymes. Research journal of medical science, 3: 1-3.
Olokoba, A. B., Bojuwoyu, B. J., Katibi, I. A., Salami, A. K., Olokoba, L. B., Braimoh, K. T., Inikori, A. K., (2006). The effect of type 2 diabetes mellitus on fasting gallbladder volume. African Scientist. 7, PP: 117-120.
Pereira-Lima, J. C., Jakobs, R., Busnello, J. V., Benz, C., Blaya, C. and Riemann, J. F., (2000). The role of serum liver enzymes in the diagnosis of choledocholithiasis. Hepatogastroenterology. 47: 1522-1525.
Rao, P. J, Jarari, A., El-Awami, H., Patil, T. N. and El-Saiety, S. O. (2012). Lipid profile in bile and serum of cholelithiasis patients-A comparative study. Journal of basic medical and Allied sciences, 1: 27-39.
Selvaraju, R., Raman, G. and Narayanaswamy, R. (2009). Change in serum trace elements concentration before and after removal of gallbladder with gallstone. The internet journal of gastroenterology, 8: 182-191
Shiina, Y., Toyoda, T., Kawasoe, Y., Tateno, S., Shirai, T., Matsuo, K., Mizuno, Y., Ai, T. and Niwa, K. (2011). The prevalence and risk factors for cholelithiasis and asymptomatic gallstones in adults with congenital heart disease. International Journal of Cardiology, 152: 171–176
Smelt, A. H., (2010). Triglyceride and gallstone formation. Clinica Chimica Acta, 411: 1625-1631.
Black, J. M and Hawks, J. H, (2004). Medical- Surgical Nursing. 7th edition, 1302-1314.
Carter, S. M. and Besa, E. C., (2012). Hemoglobin C disease. Medscape reference: 118-123.
Channa, N. A., (2008). Gall stones. Pak Arm Forces Med J., 58: 197.
Channa, N. A., Khand, F., Ghanghro, A. B. and Soomro, A. M. (2010). Quantitative analysis of serum lipid profile in gallstone patients and controls. Pak. J. Anal. Environ. Chem. 11: 59-65.
Channa. N. A., Shaikh, H. R., Khand, F. D., Bhanger, M. I. and Laghari, M. H., (2005). Association of gallstone disease risk with serum level of alkaline phosphatase. JLUMHS, 18-22.
Crema, E., Ribeiro, E. N., Hial, A. M., Alves-Júnior, J. T., Pastore, R. and Silva, A. A., (2005). Evaluation of the response of cortisol, corticotropin and blood platelets kinetics after laparoscopic and open cholecystectomy. Acta Cir Bras, 20:364-367.
Cuevas, A., Miquel, J. F., Reyes, M. S., Zanlungo, S. and Nervi, F. (2004). Diet as a Risk Factor for Cholesterol Gallstone Disease. J Am Coll Nutr, 23: 187-196
Dave, A. (last updated2010). Elevated liver enzymes and the gallbladder. M.J. Ingram, 18: 67-71
Devrajani, B. R., Muammad, A. T., Shaikh, A. A., Ali Shah, S. Z., Devrajani, T. and Das, T. (2010). Frequency of gallstone in patients with diabetes mellitus (a hospital based multidisciplinary study). Medical channel, 16: 230-232.
Fagan, S. P., Awad, S. S., Rahwan, K., Hira, K., Aoki, N., Itani, K. M. and Berger, D. H., (2003). Prognostic factors for the development of gangrenous cholecystitis. The American journal of surgery, 186: 481-485.
Habib, L., Mirza, M. R., Channa, M. A., Wasty, W. H., (2009). Role of the liver function tests in symptomatic cholelithiasis. J Ayub Med Coll Abbottabad, 21: 117-119.
Jaraari, A. M., Jagannadharar, P., Patel, T. N., Hai, A., Awamy, H. A., El-Saeity, S. O., Abdel Kafi, E. B., El-Hemri, M N., and Tayesh, M. F., (2010). Quantitative analysis of gallstones in Libyan patients. Libyan J Med, 5: 4627-4631.
Johnston, D. E., and Kaplan, M. M., (1993). Pathogenesis and Treatment of Gallstones. N Engl J Med, 328: 412-421.
Kim, Y. C., Park, M., Chung, Y. E., Lim, J. S., Kim, M. J. and Kim, K. W., (2007). Gallstone spillage caused by spontaneously perforated hemorrhagic cholecystitis. World J Gastroenterol, 13: 5525-5526.
Merriam, L. T., Kanaan, S. A. and Dawes, L. G., (1999). Gangrenous cholecystitis: analysis of risk factors and experience with laparoscopic cholecystectomy. Surgery, 126: 680-686
Olokoba, A. B., Bojuwoye, B. J., Olokoba, l. b., Braimoh, K. T., Inikori, A. K., and Abdulkareem, A. A., (2009). Relationship between gallstone disease and liver enzymes. Research journal of medical science, 3: 1-3.
Olokoba, A. B., Bojuwoyu, B. J., Katibi, I. A., Salami, A. K., Olokoba, L. B., Braimoh, K. T., Inikori, A. K., (2006). The effect of type 2 diabetes mellitus on fasting gallbladder volume. African Scientist. 7, PP: 117-120.
Pereira-Lima, J. C., Jakobs, R., Busnello, J. V., Benz, C., Blaya, C. and Riemann, J. F., (2000). The role of serum liver enzymes in the diagnosis of choledocholithiasis. Hepatogastroenterology. 47: 1522-1525.
Rao, P. J, Jarari, A., El-Awami, H., Patil, T. N. and El-Saiety, S. O. (2012). Lipid profile in bile and serum of cholelithiasis patients-A comparative study. Journal of basic medical and Allied sciences, 1: 27-39.
Selvaraju, R., Raman, G. and Narayanaswamy, R. (2009). Change in serum trace elements concentration before and after removal of gallbladder with gallstone. The internet journal of gastroenterology, 8: 182-191
Shiina, Y., Toyoda, T., Kawasoe, Y., Tateno, S., Shirai, T., Matsuo, K., Mizuno, Y., Ai, T. and Niwa, K. (2011). The prevalence and risk factors for cholelithiasis and asymptomatic gallstones in adults with congenital heart disease. International Journal of Cardiology, 152: 171–176
Smelt, A. H., (2010). Triglyceride and gallstone formation. Clinica Chimica Acta, 411: 1625-1631.
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Published
2014-06-30
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Rasheed, R. A. (2014). Lipid Profile and Hematological Changes in Gallstone Patients. Science Journal of University of Zakho, 2(1), 49–53. Retrieved from https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/104
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