Sodium Alginate - Gelatin Cross-Linked Microspheres for Releasing Diltiazem Hcl

  • Alarqam Z. Tareq University of Zakho
  • Mohammed S. Hussein University of Zakho
Keywords: drug delivery system, sodium alginate, gelatin, Semi-interpenetrating polymer network microspheres


Semi-interpenetrating polymer network (semi-IPN) microspheres of Sodium alginate (NaAlg) and Gelatin were prepared and cross-linked with glutaraldehyde by using emulsification/solvent-evaporation method to deliver Diltiazem HCl as a model of drug. Diltiazem HCl was successfully loaded into NaAlg-Gelatin microspheres in different ratios of NaAlg and Gelatin. The prepared microspheres were characterized by Fourier Transmission Infrared Microscopy (FT-IR) and Scanning Electron Microscope (SEM). The effects of different process parameters, like percentage of polymers, swelling behavior and in vitro drug release of microspheres in different phosphate buffer solutions pH (7.1and3.9) were studied. The models of kinetics of releasing drug were investigated by using different types of mechanisms (Zero-order, First order, Higuchi’s model and Hixson-Crowell model).

Author Biographies

Alarqam Z. Tareq, University of Zakho

Department of Chemistry, Faculty of Science, University of Zakho, Kurdistan Region, Iraq.

Mohammed S. Hussein, University of Zakho

Department of Chemistry, Faculty of Science, University of Zakho, Kurdistan Region, Iraq.


Babin H., Dickinson E., (2001). Influence of transglutamase treatment on the thermo reversible gelation of gelatin, Food Hydrocolloids, 15, 271-276.
Fan L., Du Y., Huang R., Wang Q., Wang X., Zhang L., (2005). Preparation and characterization of alginate/gelatin blend fibers, Journal of Applied Polymer Science, 96, 1625-1629.
Fang Y., Cheng Q., Lu X., (1998). Kinetics of in-vitro release from chitosan/gelatin hybrid membranes, Journal of Applied Polymer Science, 68, 1751-1758.
Gaur R., Azizi M., Gan J., Hansal P., Harper K., Mannan R., Panchal A., Patel K., Patel M., Patel N., Rana J., Rogowska A., (2009). British Pharmacopoeia, 1and2, 1973-1977.
Huang X., Brazel C., (2001). On the importance and mechanisms of burst release in matrix-controlled drug delivery systems, Journal of Controlled Release, 73, 121-136.
Kulkarni A., Soppimath K., Aminabhavi T., Dave A., Mehta M., (2000). Gluteraldehyde Crosslinked Sodium Alginate Beads Containing Liquid Pesticide for Soil Application, Journal of Controlled Release, 63, 1-2, 97-105.
Kumbar S., Aminabhavi T., (2002). Preparation and Characterization of Interpenetrating Network Beads of Poly(vinyl alcohol)-G-Poly(acrylamide) with Sodium Alginate and Their Controlled Release Characteristics for Cypermethrin Pesticide, Journal of Applied Polymer Science, 84, 3, 552-560.
Lavan D., McGuire T., Langer R., (2003). Small-Scale Systems for in Vivo Drug Delivery, Nature Biotechnology, 21, 10, 1184-1191.
Oakenfull D., Scott A., (2003). Gelatin gels in deuterium oxide, Food Hydrocolloids, 17, 207-210.
Peppas N., Zach H., Khademhosseini A., Langer R., (2006). Hydrogels in biology and medicine from molecular principles to bionanotechnology, Advanced Materials, 18, 1345-1360.
Pepperman A., Kuan J., (1995). Controlled Release Formulations of Alachlor Based on Calcium Alginate, Journal of Controlled Release, 34, 1, 17-23.
Pourjavadi A., Salimi H., Kurdtabar M, (2007). Hydrolyzed collagen-based hydrogel with salt and pH-responsiveness properties, Journal of Applied Polymer Science, 106, 2371-2379.
Şanlı O., Karaca İ., Işıklan N., (2009). Preparation, characterization, and salicylic acid release behavior of chitosan/poly(vinyl alcohol) blend microspheres, Journal of Applied Polymer Science, 111, 2731-2740 .
Simpson N., Stabler C., Sambanis A., Constantinidis I., (2004). The role of the CaCI2-guluronic acid interaction on alginateencapsulated bTC3 cells, Journal of Biomaterials, 25, 2603-2610.
Tapia C., Corbalan V., Costa E., Gai M., Yazdani M., (2005). Study of the release mechanism of diltiazem hydrochloride from matrices based on chitosan-alginate and chitosan-carrageenan mixtures, Biomacromolecules, 23, 89-95.
Tripathi K., (2003). Essentials of Medical Pharmacology, J.P.Medical Publishers, 5th Ed., 453-454.
How to Cite
Tareq, A., & Hussein, M. (2016). Sodium Alginate - Gelatin Cross-Linked Microspheres for Releasing Diltiazem Hcl. Science Journal of University of Zakho, 4(2), 226-235. Retrieved from
Science Journal of University of Zakho