Oxidant-Antioxidant Status and Some Related Parameters in Hypertension Diabetic (Type 1&2) Patients - in Thi-Qar /Iraq
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Abstract
Hyperglycemia is considered a major initiator of oxidative stress which lead to the formation of free radicals and consequently lipid peroxidation occurs that which lead to tissue damage and diabetes mellitus development. Therefore, the present study aims to investigate the relationship between antioxidant status and lipid peroxidation end products (malondialdehyde; MDA) and some trace elements in the plasma of 30 type 1 DM patients and 30 type 2 DM patients and 40 hypertension DM patients (20 type1 and 20 type2) and 30 non hypertension DM patients (15 type1 and15 type2) and 40 non diabetic healthy control subjects.Plasma MDA, chromium and ceruloplasmin concentrations was measured by manual methods, whereas glucose, iron, copper, transferrin and albumin concentrations were analyzed spectrophotometrically by kits in all patients with DM as well as in the control subjects. The results of type1DM were compared with type2DM and hypertension-DM were compared with a non- hypertension DM and control group using One way ANOVA-test to compare parameters in different studied groups.The results show a significant elevation (P ≤ 0.05) in levels of glucose, MDA, iron, copper and ceruloplasmin of type 2- diabetic patients in comparison type 1-diabetic patients and healthy subjects, also, it has been found a significant decrease (P ≤ 0.05) in chromium, transferrin and albumin levels in type 2- diabetic patients in comparison with type 1- diabetic patients and control group. Also the results show a significant elevation (P ≤ 0.05) in levels of glucose, MDA, chromium, iron, copper and ceruloplasmin of (type1 and type 2) hypertension- diabetic patients in comparison (type 1and type2) non hypertension-diabetic patients and healthy subjects, also, it has been found a significant decrease (P ≤ 0.05) in transferrin and albumin levels (type1 and type 2) hypertension- diabetic patients in comparison (type1and type2) non hypertension-diabetic patients and healthy subjects.
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Copyright (c) 2013 Ra’id M. H. Al- Salih, Hutaf B. Farhood
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