One-Pot Synthesis, Pharmacological Evaluation, Docking Study, and DFT Calculations for Selected Imidazolidine-2,4-Diones

Authors

  • Zanko S. Jawhar Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Hawler, Kurdistan Region, Iraq.
  • Hiwa O. Ahmad Department of Pharmaceutical Chemistry, College of Pharmacy, Hawler Medical University, Hawler, Kurdistan Region, Iraq.
  • Asmaa A. Haydar Department of pharmacology, College of Pharmacy, Hawler Medical University, Hawler, Kurdistan Region, Iraq.
  • Halala A. Abdullah Department of chemistry, College of Science, Soran University, Kurdistan Region, Iraq.
  • Sawza A. Mahamad Department of chemistry, College of Science, Soran University, Kurdistan Region, Iraq.

DOI:

https://doi.org/10.25271/sjuoz.2018.6.4.541

Keywords:

imidazolidine-2, 4-dione derivatives, Prostate cancer, computational study, Energy, biological activity

Abstract

The title compounds with different 5-substituted imidazolidine-2,4-dione were synthesized through a solvent-free reaction. Imidazolidine-2,4-dione derivatives are found to be an active pharmacophore for design and development of various bioactive lead compounds.  Positive values of energy obtained for compound 1and 3, while a negative value for compound 2 was calculated by DFT in Gaussian. keto-enol tautomerism was supported by energy values  and indicated the most stable tautomeric form. The biological evaluation has been supported by docking studies using molecular operating environment program to show binding with androgen receptor. 

Supplementary Materials: https://sjuoz.uoz.edu.krd/suppma

Author Biographies

Zanko S. Jawhar, Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Hawler, Kurdistan Region, Iraq.

Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Hawler, Kurdistan Region, Iraq.

Hiwa O. Ahmad, Department of Pharmaceutical Chemistry, College of Pharmacy, Hawler Medical University, Hawler, Kurdistan Region, Iraq.

Department of Pharmaceutical Chemistry, College of Pharmacy, Hawler Medical University, Hawler, Kurdistan Region, Iraq.

Asmaa A. Haydar, Department of pharmacology, College of Pharmacy, Hawler Medical University, Hawler, Kurdistan Region, Iraq.

Department of pharmacology, College of Pharmacy, Hawler Medical University, Hawler, Kurdistan Region, Iraq.

Halala A. Abdullah, Department of chemistry, College of Science, Soran University, Kurdistan Region, Iraq.

Department of chemistry, College of Science, Soran University, Kurdistan Region, Iraq.

Sawza A. Mahamad, Department of chemistry, College of Science, Soran University, Kurdistan Region, Iraq.

Department of chemistry, College of Science, Soran University, Kurdistan Region, Iraq.

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Published

2018-12-30

How to Cite

Jawhar, Z. S., Ahmad, H. O., Haydar, A. A., Abdullah, H. A., & Mahamad, S. A. (2018). One-Pot Synthesis, Pharmacological Evaluation, Docking Study, and DFT Calculations for Selected Imidazolidine-2,4-Diones. Science Journal of University of Zakho, 6(4), 150–154. https://doi.org/10.25271/sjuoz.2018.6.4.541

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Science Journal of University of Zakho