Flow Injection Chemiluminescence Determination of Acetylsalicylic Acid in Pharmaceutical Formulations
Keywords:
Flow Injection, Chemiluminescence, Acetylsalicylic Acid, Luminol-Hydrogen Peroxide, Potassium Hexacyanoferrate, PharmaceuticalsAbstract
A simple and sensitive flow injection chemiluminescence method was proposed for the determination of acetylsalicylic acid (aspirin) in pharmaceutical formulations. The method was based on inhibition effect of acetylsalicylic acid on the chemiluminescence reaction of luminol–hydrogen peroxide and potassium hexacyanoferrate. Different experiment parameters affecting the chemiluminescence intensity were carefully studied and incorporated into the procedure. The detection limit was 0.5 μg/mL of acetylsalicylic acid, and chemiluminescence emission intensity was correlated with the drug concentration in the range 2.5-125 μg/mL with correlation coefficient of 0.9985 and analytical frequency of 75 determinations per hour. The results obtained for the assay of pharmaceutical formulations were compared well with those obtained by the official method in British Pharmacopoeia and demonstrated good accuracy and precision.
References
Abdelrahman, M. M. (2014). Selective spectrophotometric methods for determination of ternary mixture with overlapping spectra: A comparative study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 124, 389–396.
Alves, J. C., & Poppi, R. J. (2009). Simultaneous determination of acetylsalicylic acid, paracetamol and caffeine using solid-phase molecular fluorescence and parallel factor analysis. Analytica Chimica Acta, 642(1-2), 212-216.
Boixa, C., Ibanez, M., Sancho, J. V., Rambla, J., Aranda, J. L., Ballester, S., & Hernandez, F. (2015). Fast determination of 40 drugs in water using large volume direct injection liquid chromatography-tandem mass spectrometry. Talanta, 131, 719–727.
British Pharmacopoeia. (2009). (Vol. I and II). London, UK: Crown Copyright.
Collaboration, A. T. (2002). Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. British Medical Journal, 324, 71-86.
El-Din, M. S., Eid, M., & Zeid, A. M. (2013). Simultaneous determination of methocarbamol and aspirin by RP-HPLC using fluorescence detection with time programming: its application to pharmaceutical dosage form. Luminescence, 28(3), 332–338.
Elmasry, M. S., Blagbrough, I. S., Rowan, M. G., Saleh, H. M., Kheir, A. A., & Rogers, P. J. (2011). Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines. Journal of Pharmaceutical and Biomedical Analysis, 54(4), 646–652.
Gorodetsky, R. (2014). Encyclopedia of toxicology (3 ed. Vol. 1). New York, USA: Elsevier.
Harris, D. C. (2009). Exploring chemical analysis. USA: W. H. Freeman and Company.
Jabbar, H. S., & Faizullah, A. T. (2013). A novel chemiluminescence assay of ethylene glycol in antifreeze samples using FIA with merging zone principle. British Journal of Applied Science & Technology, 3(4), 1414-1429.
Lopez-Fernandez, J. M., Castro, M. D., & Valcarcel, M. (1990). Automatic continuous on-line monitoring of salicylic acid and acetylsalicylic acid in pharmaceuticals. Journal of Automatic Chemistry, 12(6), 263-266.
Malisetty, S. K., & Rambabu, C. (2013). Simultaneous determination of aspirin and esomeprazole magnesium in combined tablets by validated UPLC method. Pharmaceutical Methods, 4(1), 26–29.
Marjan, M. N., Hamzeh, M. T., Rahman, E., & Sadeq, V. (2014). A computational prospect to aspirin side effects: Aspirin and COX-1 interaction analysis based on non-synonymous SNPs. Computational Biology and Chemistry, 51, 57–62.
Marra, M. C., Cunha, R. R., Vidal, D. T., Munoz, R. A., Lagob, C. L., & Richter, E. M. (2014). Ultra-fast determination of caffeine, dipyrone, and acetylsalicylic acidby capillary electrophoresis with capacitively coupled contactlessconductivity detection and identification of degradation products. Journal of Chromatography A, 1327, 149–154.
Pasekova, H., Sales, M. G., Montenegro, M. C., Araujo, A. N., & Polasek, M. (2001). Potentiometric determination of acetylsalicylic acid by sequential injection analysis (SIA) using a tubular salicylate-selective electrode. Journal of Pharmaceutical and Biomedical Analysis, 24(5), 1027–1036.
Pereira, A. V., Aniceto, C., & Fatibello-Filho, O. (1998). Flow injection spectrophotometric determination of acetylsalicylic acid in tablets after on-line microwave-assisted alkaline hydrolysis. Analyst, 123(5), 1011-1015.
Roth, G. J., & Majerus, P. W. (1975). The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein. Journal of Clinical Investigation, 56, 624-632.
Sanghavi, B. J., & Srivastava, A. K. (2010). Simultaneous voltammetric determination of acetaminophen, aspirin and caffeine using an in situ surfactant-modified multiwalled carbon nanotube paste electrode. Electrochimica Acta, 55(28), 8638–8648.
Sena, M. M., & Poppi, R. J. (2004). N-way PLS applied to simultaneous spectrophotometric determination of acetylsalicylic acid, paracetamol and caffeine. Journal of Pharmaceutical and Biomedical Analysis, 34(1), 27–34.
Singh, G., & Triadafilopoulos, G. (1999). Epidemiology of NSAID induced gastrointestinal complications. Journal of Rheumatology Supplement, 56, 18-24.
Skoog, D. A., West, D. M., Holler, F. J., & Crouch, S. R. (2004). Fundamentals of analytical chemistry (8 ed.). USA: Brooks/Cole-Thomson Learning.
Torriero, A. A., Luco, J. M., Sereno, L., & Raba, J. (2004). Voltammetric determination of salicylic acid in pharmaceuticals formulations of acetylsalicylic acid. Talanta, 62(2), 247–254.
Wabaidur, S. M., Alam, S. M., Alothman, Z. A., & Eldesoky, G. (2014). Flow-injection chemiluminescence determination of acetylsalicylic acid based on its enhancing effect on the lucigenin–hydrogen peroxide system. Luminescence, 29(6), 684–688.
Yamamoto, E., Takakuwa, S., Kato, T., & Asakaw, N. (2007). Sensitive determination of aspirin and its metabolites in plasma by LC-UV using on-line solid-phase extraction with methylcellulose-immobilized anion-exchange restricted access media. Journal of Chromatography B, 846(1–2), 132–138.
Zadeh, H. A., Kohansal, S., & Sadeghi, G. H. (2011). Nickel–aluminum layered double hydroxide as a nanosorbent for selective solid-phase extraction and spectrofluorometric determination of salicylic acid in pharmaceutical and biological samples. Talanta, 84(2), 368–373.
Alves, J. C., & Poppi, R. J. (2009). Simultaneous determination of acetylsalicylic acid, paracetamol and caffeine using solid-phase molecular fluorescence and parallel factor analysis. Analytica Chimica Acta, 642(1-2), 212-216.
Boixa, C., Ibanez, M., Sancho, J. V., Rambla, J., Aranda, J. L., Ballester, S., & Hernandez, F. (2015). Fast determination of 40 drugs in water using large volume direct injection liquid chromatography-tandem mass spectrometry. Talanta, 131, 719–727.
British Pharmacopoeia. (2009). (Vol. I and II). London, UK: Crown Copyright.
Collaboration, A. T. (2002). Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. British Medical Journal, 324, 71-86.
El-Din, M. S., Eid, M., & Zeid, A. M. (2013). Simultaneous determination of methocarbamol and aspirin by RP-HPLC using fluorescence detection with time programming: its application to pharmaceutical dosage form. Luminescence, 28(3), 332–338.
Elmasry, M. S., Blagbrough, I. S., Rowan, M. G., Saleh, H. M., Kheir, A. A., & Rogers, P. J. (2011). Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines. Journal of Pharmaceutical and Biomedical Analysis, 54(4), 646–652.
Gorodetsky, R. (2014). Encyclopedia of toxicology (3 ed. Vol. 1). New York, USA: Elsevier.
Harris, D. C. (2009). Exploring chemical analysis. USA: W. H. Freeman and Company.
Jabbar, H. S., & Faizullah, A. T. (2013). A novel chemiluminescence assay of ethylene glycol in antifreeze samples using FIA with merging zone principle. British Journal of Applied Science & Technology, 3(4), 1414-1429.
Lopez-Fernandez, J. M., Castro, M. D., & Valcarcel, M. (1990). Automatic continuous on-line monitoring of salicylic acid and acetylsalicylic acid in pharmaceuticals. Journal of Automatic Chemistry, 12(6), 263-266.
Malisetty, S. K., & Rambabu, C. (2013). Simultaneous determination of aspirin and esomeprazole magnesium in combined tablets by validated UPLC method. Pharmaceutical Methods, 4(1), 26–29.
Marjan, M. N., Hamzeh, M. T., Rahman, E., & Sadeq, V. (2014). A computational prospect to aspirin side effects: Aspirin and COX-1 interaction analysis based on non-synonymous SNPs. Computational Biology and Chemistry, 51, 57–62.
Marra, M. C., Cunha, R. R., Vidal, D. T., Munoz, R. A., Lagob, C. L., & Richter, E. M. (2014). Ultra-fast determination of caffeine, dipyrone, and acetylsalicylic acidby capillary electrophoresis with capacitively coupled contactlessconductivity detection and identification of degradation products. Journal of Chromatography A, 1327, 149–154.
Pasekova, H., Sales, M. G., Montenegro, M. C., Araujo, A. N., & Polasek, M. (2001). Potentiometric determination of acetylsalicylic acid by sequential injection analysis (SIA) using a tubular salicylate-selective electrode. Journal of Pharmaceutical and Biomedical Analysis, 24(5), 1027–1036.
Pereira, A. V., Aniceto, C., & Fatibello-Filho, O. (1998). Flow injection spectrophotometric determination of acetylsalicylic acid in tablets after on-line microwave-assisted alkaline hydrolysis. Analyst, 123(5), 1011-1015.
Roth, G. J., & Majerus, P. W. (1975). The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein. Journal of Clinical Investigation, 56, 624-632.
Sanghavi, B. J., & Srivastava, A. K. (2010). Simultaneous voltammetric determination of acetaminophen, aspirin and caffeine using an in situ surfactant-modified multiwalled carbon nanotube paste electrode. Electrochimica Acta, 55(28), 8638–8648.
Sena, M. M., & Poppi, R. J. (2004). N-way PLS applied to simultaneous spectrophotometric determination of acetylsalicylic acid, paracetamol and caffeine. Journal of Pharmaceutical and Biomedical Analysis, 34(1), 27–34.
Singh, G., & Triadafilopoulos, G. (1999). Epidemiology of NSAID induced gastrointestinal complications. Journal of Rheumatology Supplement, 56, 18-24.
Skoog, D. A., West, D. M., Holler, F. J., & Crouch, S. R. (2004). Fundamentals of analytical chemistry (8 ed.). USA: Brooks/Cole-Thomson Learning.
Torriero, A. A., Luco, J. M., Sereno, L., & Raba, J. (2004). Voltammetric determination of salicylic acid in pharmaceuticals formulations of acetylsalicylic acid. Talanta, 62(2), 247–254.
Wabaidur, S. M., Alam, S. M., Alothman, Z. A., & Eldesoky, G. (2014). Flow-injection chemiluminescence determination of acetylsalicylic acid based on its enhancing effect on the lucigenin–hydrogen peroxide system. Luminescence, 29(6), 684–688.
Yamamoto, E., Takakuwa, S., Kato, T., & Asakaw, N. (2007). Sensitive determination of aspirin and its metabolites in plasma by LC-UV using on-line solid-phase extraction with methylcellulose-immobilized anion-exchange restricted access media. Journal of Chromatography B, 846(1–2), 132–138.
Zadeh, H. A., Kohansal, S., & Sadeghi, G. H. (2011). Nickel–aluminum layered double hydroxide as a nanosorbent for selective solid-phase extraction and spectrofluorometric determination of salicylic acid in pharmaceutical and biological samples. Talanta, 84(2), 368–373.
Downloads
Published
2016-06-30
How to Cite
Jabbar, H. S. (2016). Flow Injection Chemiluminescence Determination of Acetylsalicylic Acid in Pharmaceutical Formulations. Science Journal of University of Zakho, 4(1), 94–103. Retrieved from https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/310
Issue
Section
Science Journal of University of Zakho
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License [CC BY-NC-SA 4.0] that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work, with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online.
