Evaluation of Oxidation – Antioxidation Balance in Sera of Patients with Acute Hepatitis Virus Type C.

  • Rasha H. Jasim University of Kufa-Iraq
Keywords: lipid peroxidation, malondialdehyde, ceruloplasmin


Aim of the present study has to focused on the possible relationship between serum malondialdehyde level, an index of lipid peroxidation, and ceruloplasmin levels, as protective agent against lipid peroxidation, in hepatitis C virus. A group of 31 hepatitis virus type C patients were enrolled in the study, while; control group consisted of 25 healthy subjects. In the present study, total proteins (g/L), malondialdehyde (µM), ceruloplasmin oxidase activity (U/L) and ceruloplasmin concentration (g/L) were measured in sera samples of patients with hepatitis C virus as well as in the healthy controls.

Author Biography

Rasha H. Jasim, University of Kufa-Iraq

Chemistry Department-College of  Education for Girls-University of Kufa-Iraq


Aigner E and Datez C. [2008]: Iron Perturbations in Human Non-Alcoholic Fatty Liver Disease (NAFLD): Clinical Relevance and Molecular Mechanisms. Hepatitis Monthly. 8(3): 213-220.
Aksoy H, Koruk M, and Akçay F. [2003]:The Relationship Between Serum Malondialdehyde and Ceruloplasmin in Chronic Liver Disease. Turkish Journal of Biochemistry. 28 (2): 32-34.
Albert J C and Deborah K F.[2012]: Diagnosis And Treatment Of Autoimmune Hepatitis. Hematology. 36(2):479-497.
Al-Faham R. [2002]: A Biochemical Study of Serum Sialic Acid and Lectins Activity as Tumor Markers for Gastrointestinal Tract Cancers. University of Kufa, College of Education, Chemistry Department. Thesis.
Brewer G J, Kanzer S H, Zimmerman E A, Celmins D F, Heckman S M.[2010]: Copper and Ceruloplasmin Abnormalities in Alzheimer’s Disease. American Journal of Alzheimer’s Disease. 25 (6): 490-497.
Bush A I. [2010]: Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease. Cell Journal. 142(6): 857-867.
Fujinaga H, Tsutsumi T, Yotsuyanagi H, Moriya K, And Koike K. [2011]: Hepatocarcinogenesis In Hepatitis C: HCV Shrewdly Exacerbates Oxidative Stress By Modulating Both Production And Scavenging Of Reactive Oxygen Species. Oncology. 81(1):11-17.
Ghorbani G A, Alavian S M, and Ghadimi H R. [2008]: Long Term Effect of One or Two Doses of Hepatitis C Vaccine in Adult after Five Years. Pakistan Journal of Biological Sciences. 11(4): 660-663.
Görenek L, Acar A, Aydın A, Eyigun C P, Çetinkaya A, Eken A, and Sayal A. [2006]: Oxidative Stress And Antioxidant Defense In Patients With Chronic Hepatitis C Patients Before And After Pegylated Interferon Alfa-2b Plus Ribavirin Therapy. Journal of Translational Medicine. 4(25): 1-6.
Haimin C, Xiaojun Y, Peng Z, and Jing L. [2006]: Antioxidant Activity And Hepatoprotective Potential Of Agaro-Oligosaccharides In Vitro And In Vivo. Nutrition Journal. 5(3): 1-12.
Harliansyah A H, Noor A M, Wan Z, and Yasmin A M. [2005]: Effects of Zingiber officinale on Superoxide Dismutase, Glutathione Peroxidase, Catalase, Glutathione and Malondialdehyde Content in HepG2 Cell Line. Malaysian Journal of Biochemistry and Molecular Biology. 11, 36-41.
Janaia A V and Suprapaneni K M. [2010]: Antioxidant Vitamins And Enzymes Status In Patients With Alcoholic Liver Disease. Journal of Clinical and Diagnostic Research. 4(4): 2742-2747.
Jasim R H. [2009]: Isolation, Purification, and Partial Characterization of Human Lectins from Patients of Kidney Tumors. Baghdad University, College of Science for Women, Chemistry Department. Treatise.
Jasim R H. [2011]: Serum Malondialdehyde And Lipid Profile Levels Of Young Patients "Haven’t A Family History Of Hypertension": A New Study For Cases In The Civic Society. Pakistan Journal Of Chemistry.1(3): 120-125.
Jasim R H. [2011]:Evaluation of Oxidative-Antioxidative Balance in Serum of Patients With Non Acute Hepatitis Virus Type B. Under publishing (Participated in the 2011 International Conference on Chemistry and Chemical Process – ICCCP 2011 )
Ko W, Guo C, Yeh M, Lin L, Hsu G W, Chen P, Luo M, and Lin C. [2005]: Blood Micronutrient, Oxidative Stress, and Viral Load in Patients with Chronic Hepatitis C. World Journal of Gastroenterology. 11(30):4697-4702.
McGrath L, Mc Gleenon B, Brennan S, McColl D, McIlroy S, and Passmore A. [2001]: Increased Oxidative Stress in Alzheimer's Disease as Assessed with 4-Hydroxynonenal but not Malondialdehyde. Q J Med. 94: 485-490.
Mehmet K, Seyithan T, Cemil S, Omer Y, Fatih A, and Metin K. [2004]: Oxidative Stress and Enzymatic Antioxidant Status in Patients with Nonalcoholic Steatohepatitis. Annals of Clinical and Laboratory Science. 34(1): 57-62.
Merle U, Weiss K H, Eisenbach C, Tuma S, Ferenci P, and Stremmel W. [2010]: Truncating Mutations in the Wilson Disease Gene ATP7B are Associated with Very Low Serum Ceruloplasmin Oxidase Activity and An Early Onset of Wilson Disease. BMC Gastroenterology. 10(8): 2-6.
Moreno-Otero R and Trapero-Marugán M. [2010]: Hepatoprotective Effects of Antioxidants in Chronic Hepatitis C. World Journal of Gastroenterol.16(15): 1937-1938 .
Mustafa C, Semiha D, Fahri B, Hüseyin Ç, Fatma C, and Nihat M. [2006]: Relationship Between Antioxidant Capacity And Oxidative Stress In Children With Acute Hepatitis A. World Journal of Gastroenterology. 12(38): 6212-6215.
Nikam S, NikamP, Ahaley S K. [2009]: Role of Free Radical and Antioxidant Imbalance in Pathogenesis of Parkinson's Disease. Biomedical Research. 20 (1): 55-58.
Patel B N, Dunn R J, Jeong S Y, Zhu Q, Julien J, and David S. [2002]: Ceruloplasmin Regulates Iron Levels in the CNS and Prevents Free Radical Injury. The Journal of Neuroscience. 22(15): 6578-6586.
Plummer A. [1971]: An Introduction to Practical Biochemistry. 1st Edition. Mcgraw Hill. Book Company. London. U K.
Porter G T, Pou A M, Quinn F B, & Ryan M W. [2003]: Nutritional Considerations for Head and Neck Cancer Patients. Grand Rounds Presentation, UTMB, Department of Otolaryngology.
Raymond R W. [2007]: Biochemistry of Cancer. In: Cancer Biology. Section 1.p 108-120.
Rice E W. [1962]: Ceruloplasmin Assay in Serum: Standardization of Ceruloplasmin Activity in Terms of International Enzyme Unit "Standard Methods of Clinical Chemistry". 4th Eddition, Siligson D., New York, Academic press.
Sahu S, Abraham R, Vedavallir R, and Daniel M. [2009]: Study of Lipid Profile, Lipid Peroxidation, and Vitamin E in Pregnancy Induced Hypertension. Indian Journal of Physiology Pharmacology. 53 (4): 365–369.
Saravanamuttu G I, Samreen M J, Ramsay M, Jonathan G.[2007]: International Public Health Repository for Hepatitis C. Nucleic Acid Research. 35(2): 367-370.
Sumit B, Mukul P A, Dwivedi S, and Banerjee BD. [2008]: Monitoring Oxidative Stress Across Worsening Child Pugh Class Of Cirrhosis. Indian Journal of Medical Science. 62(11): 444-451.
Ulrich S. [2012]: Diagnosis, Prognosis and Therapy of Hepatocellular Carcinoma.in heamatology. Flying Publisher.UK.
Vera G V, Goran G, Senijo P, Antonio S, Ana-Marija D, Dubravka F, Maja P. [2012]: Assessment of cytogenetic damage and oxidative stress in personnel occupationally exposed to the pulsed microwave radiation of marine radar equipment. International Journal of Hygiene and Environmental Health. 38(2): 1438-1449.
Viorica L A, William H R, and Kirk L. [2009]: Ceruloplasmin levels in human sera from various diseases and their correlation with patient’s age and gender. Health. 1(2),104-110.
Yagi K. [1982]: Assay for Lipid Peroxide Level and Its Clinical Significance. In: Yagi K Editor Lipid Peroxides in Biology and Medicine, New York. p233–242.
How to Cite
Jasim, R. (2013). Evaluation of Oxidation – Antioxidation Balance in Sera of Patients with Acute Hepatitis Virus Type C. Science Journal of University of Zakho, 1(2), 715-722. Retrieved from https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/374
Science Journal of University of Zakho