Synthesis of Assigned Structure of Cairomycin A, 6-Isopropyl-2,5-Diketopiperazine-3-Acetic Acid and Its Β-Lactam Analogue N`- (3-Methyl-1-Hydroxybutyr-2-Yl) Azetidin-2-One-4-Carboximide

  • Faiq H. S. Hussain TIU-Research Center, Tishk International University, Erbil, Kurdistan region-Iraq
Keywords: Cairomycin A, 2,5-Diketonpiperazine, β-Lactam, Azetidine, Antimicrobial

Abstract

In the present investigation, the research carried out into the total synthesis of the assigned structure of cairomycin A, 6-isopropyl-2,5-diketopiperazine-3-acetic acid from its precursors L-valine and L-aspartic acid, and its analogue N`-(3-methyl-1-hydroxybutyr-2-yl)azetidin-2-one-4-carboximide from 4-vinylazetidi-2-one through two different sequence reactions. Structures of the synthesized products were identified by using chemical and physical methods such as elemental analysis, IR, 1H-NMR and MS. The obtained results were compared with those reported, it was found that neither of the synthesized compounds was Cairomycin A.

Author Biography

Faiq H. S. Hussain, TIU-Research Center, Tishk International University, Erbil, Kurdistan region-Iraq

TIU-Research Center, Tishk International University, Erbil, Kurdistan region-Iraq (faiq.hussain@ishik.edu.iq)

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Published
2019-12-30
How to Cite
Hussain, F. (2019). Synthesis of Assigned Structure of Cairomycin A, 6-Isopropyl-2,5-Diketopiperazine-3-Acetic Acid and Its Β-Lactam Analogue N`- (3-Methyl-1-Hydroxybutyr-2-Yl) Azetidin-2-One-4-Carboximide. Science Journal of University of Zakho, 7(4), 144-151. https://doi.org/10.25271/sjuoz.2019.7.4.638
Section
Science Journal of University of Zakho