THERAPEUTIC EFFECTS OF Cratargus azarolus VAR. aronia IN UROLITHIATIC MALE ALBINO RATS
Research Article
DOI:
https://doi.org/10.25271/sjuoz.2023.11.2.1106Keywords:
Crataegus aronia, ethylene glycol, renal calculi, lipid profilesAbstract
The study was designed to investigates the therapeutic roles of Crataegus azarolus Var. aronia L. (C. aronia) in kidney stone treatment male albino rats’ model induced by ethylene glycol (EG). Twenty animals weighing 220–270 g were divided into control group which set as group A, while the rats in B and C groups, received 1% EG for 28 days, but group C also received C. aronia (7.5g of plant/100ml water and 10g of plant/ 90 g diet) from day 15 to 28. Kidney function tests, liver function tests, serum electrolytes, serum lipid profiles, and glucose were measured. The obtain body weight, kidneys' weight and kidneys' weight/ body weight were measured, in addition microscopic analysis of formed crystals from urine was studied. Crataegus aronia administration showed a marked declination in serum creatinine, urea, cholesterol, triglyceride (TG), very low-density lipoprotein (VLDL), and non-high density lipoprotein cholesterol (non-HDL cholesterol) inverse to rats received EG. Also, the obtain body weight, kidneys' weight and kidneys' weight/ body weight markedly decreased in C group when compared to group B. In conclusion: C. aronia has clear therapeutic actions on formed kidney stone might be used employee as natural antiurolithiasis drug.
References
Abdulla, I. T., Mahmud, S. A., & Khdhr, A. R., (2017). Histological effects of melatonin on testes in pinealectomized and normal albino rats. Tikrit Journal of Pure Science, 22 (9), 34-39.
Abu-Gharbieh, E., & Shehab, N.G. (2017). Therapeutic potentials of Crataegus azarolus var. eu- azarolus Maire leaves and its isolated compounds. BMC Complementary and Alternative Medicine, 17:218.
Agiel, N., Hanoğlu, D.Y., Hanoğlu, A., Başer, K.H.C., & Mericli, F. (2019). Volatile Oil Constituents of Crataegus azarolus L. and Crataegus pallasii Grisb. Rec. Nat. Prod., 13(5), 405-412.
Ahmed, K.A., & Mahmud, S.A. (2021). Curative Effects Of Ethanol Extract Of Prosopis farcta (Syrian Mesquite) Against Ethylene Glycol Induced Urolithiasis In Male Albino Rats. Science Journal of University of Zakho, 9(2), 89-96.
Ahmed, S., Gilani, S.M.U., & Hasan, M.M. (2017). Antiurolithiatic potential of globally used medicinal plants belonging to the family Rosaceae. Journal of Pharmacognosy and Phytochemistry, 6(4): 1028-1031.
Ahmed, S., Hasan, M.M., & Mahmood, Z.A. (2016). Antiurolithiatic plants: Multidimensional pharmacology. Journal of Pharmacognosy and Phytochemistry, 5(2): 04-24.
Al-Bajari, S.A., Younis, H.A., & Raoof, S.A. (2019). Antiurolithiatic Activity of the Plant Extracts Ofannonaon Ethylene Glycol Induced Urolithiasis in Rabbits. Indian Journal of Forensic Medicine & Toxicology, 13 (4).
Alelign, T., & Petros, B. (2018). Kidney stone disease: an update on current concepts. Advances in urology, 2018.
Al-Habib, O.A.M., Mahmud, S.A., & Vidari, G. (2015). Anti-Contraction Effects of Euscaphic AcidI solated from Crataegus azarolus var. aronia L on Rat’s Aortic Smooth Muscle. Advances in Life Science and Technology, 33, 48-60.
Alirezalu, A., Ahmadi, N., Salehi, P., Sonboli, A., Alirezalu, K., Khaneghah, A.M., Barba, F.J., Munekata, P.E.S., & Lorenzo, J.M. (2020). Physicochemical Characterization, Antioxidant Activity, and Phenolic Compounds of Hawthorn (Crataegus spp.) Fruits Species for Potential Use in Food Applications. Foods, 9, 436.
Al-Mobideen, O.K., Alqudah, A.A., Al-Mustafa, A., Alhawarat, F., & Mizher, H., (2022). Effect of crataegus aronia on the biochemical parameters in induced diabetic rats. Pharmacogn J., 14(5): 587-595.
Al-Snafi, A.E. (2018). Arabian medicinal plants with antiurolithiatic and diuretic effects - plant based review (Part 1). IOSR Journal Of Pharmacy, 8(6), 67-80.
Arafat, O.M., Tham, S.Y., Sadikum, A., Zhari, I., Haughton, P.J., & Asmawi, M.Z. (2008). Studies on diuretic and hypouricemic effects of Orthosiphon stamineus. J Ethnopharmacol, 118:354–360. https://doi.org/10.1016/j.jep.2008.04.015 Epub 2008 Apr 22.
Arshad, Z., Abrar, A., Nosheen, S., & Mughal, T. (2020). Determining cadmium levels in herbal tooth powders purchased from street markets in Lahore, Pakistan. Kuwait J. Sci., 47 (1): 79-85.
Arya, P., Pandey, S., & Verma, V. (2017). Kidney stones formation and use of medicinal plants as antiurolithiatic agents. Universal Journal of Pharmaceutical Research, 2(4): 42- 48.
Bahmani, M., Baharvand-Ahmadi, B., Tajeddini, P., Rafieian-Kopaei, M., & Naghdi, N. (2016). Identification of medicinal plants for the treatment of kidney and urinary stones. Journal of renal injury prevention, 5(3): 129-133.
Bahri-Sahloul, R., Ammar, S., Grec, S., & Harzallah-Skhiri, F. (2015). “Chemical characterisation of Crataegus azarolus L. fruit from 14 genotypes found in Tunisia.” Journal of Horticultural Science and Biotechnology, 84, 23–28.
Bahri-Sahloul, R., Fredj, R.B., Boughalleb, N., Shriaa, J., Saguem, S., Hilbert, J.L., Trotin, F., Ammar, S., Bouzid, S., & Harzallah-Skhiri, F. (2014). Phenolic Composition and Antioxidant and Antimicrobial Activities of Extracts Obtained from Crataegus azarolus L. var. aronia (Willd.) Batt. Ovaries Calli. Hindawi Publishing Corporation Journal of Botany, Volume 2014, 11 pages.
Byahatti, V.V.; Pai, K.V., & D’Souza, M.G. (2010). Effects of phenolic compounds from Bergenia ciliata (Haw.) Stern. Leaves on experimental kidney stones. Ancient science of life, 30(1): 14-17.
Cheraft-bahloul, N., Husson, C., Ourtioualous, M., Sinaeve, S., Atmani, D., Stévigny, C., Nortier, J.L., & Antoine, M.H. (2017). Protective effects of pistacia lentiscus l. Fruit extract against calcium oxalate monohydrate induced proximal tubular injury. Journal of ethnopharmacology, 209, 248-254.
Choi, H.S., Seo, H.S., Kim, S.R., Choi, Y.K., Shin, Y.C., & Ko, S.G. (2014). Antiinflammatory and anti-proliferative effect of herbal medicines (APR) in RAW264.7 cells. Mol Med Rep., 9:1569–74.
Dinesh, K., Vikrant, A., Zulfiqar, A.B., Nisar, A.K., & Deo, N.P. (2012). The genus Crataegus: chemical and pharmacological perspectives. Rev. Bras. Farmacogn., 22, 1187-1200.
Gaire, B.P. (2018). Herbal Medicine in Ischemic Stroke: Challenges and Prospective. Chinese Journal of Integrative Medicine, 24, 243–246.
Garcia, M.T.H., Malaguit, C.J.A., Verte, A.J.D., Cometa, R.P., Dimayacyac, M.E., Taganap, A.B.P., Quintia, M.C.A.F., Aguila, S.C., & Villalobos, O.A. (2018). Antiurolithiatic activity of ethanolic extract of Eleusine indica Linn. (Poaceae) leaves in ethylene glycol-induced urolithiasis in male Sprague Dawley rats. Asia Pacific Journal of Allied Health Sciences, 1.
Golshan, A., Hayatdavoudi, P., Mousa, A., Rad, A.K., Roshan, N.M., Abbasnezhad, A., Mousavi, S.M., Pakdel, R., Zarei, B., & Aghaee, A. (2017). Kidney stone formation and antioxidant effects of Cynodon dactylon decoction in male wistar rats. Avicenna journal of phytomedicine, 7: 180-190.
Grases, F., Prieto, R.M., Fernandez-Cabot, R.A., Costa-Bauzá, A., Tur, F. et al. (2015). Effects of polyphenols from grape seeds on renal lithiasis. Oxidative medicine & cellular longevity, volume 2015. http:// dx.doi.org/10.1155/2015/813737
Gupta, S., & Shamsher, S. (2018). Kidney stones: mechanism of formation, pathogenesis and possible treatments. J. Biomol. Biochem, 2, 1-5.
Hameed, S.I., Al-Shahwany, A.W., & Salih, S.J. (2019). Investigation the potential role of some medicinal plants extracts in regulating serum lipid profile in female albino rats. Iraqi Journal of Science, 60(12), 2561-2571.
Hellenbrand, N., Sendker, J., Lechtenberg, M., Petereit, F., & Hensel A. (2015). Isolation and quantification of oligomeric and polymeric procyanidins in leaves and flowers of Hawthorn (Crataegus spp.). Fitoterapia, 104, 14–22.
Janbaz, K.H., Latif, M.F., Saqib, F., Imran, I., Zia-Ul-Haq, M., & De Feo, V. (2013). "Pharmacological Effects of Lactuca Serriola L. In Experimental Model of Gastrointestinal, Respiratory, and Vascular Ailments." Evidence-Based Complementary and Alternative Medicine. Vol. 2013.
Kallassy, H., Fayyad-Kazan, M., Makki, R., EL-Makhour, Y., Hamade, E., Rammal, H., Leger, D.Y., Sol V., Fayyad-Kazan, H., Liagre, B., & Badran, B. (2017). Chemical Composition, Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of the Plant Lebanese Crataegus azarolus L. Med Sci Monit Basic Res, 23, 270–284.
Karimi, M., Naghdi, N., Haddadi, S.N., & Bahmani, F. (2017). Medicinal plants used for kidney pain. J. Pharm. Sci. and Res., 9(5), 542-546.
Kaushik, S., Choudhary, M., & Rajpal, S. (2021). Antiurolithiatic efficacy of combination preparations of Dolichos biflorus and Crataeva nurvala: folk medicines used in Indian traditional medicine. Future Journal of Pharmaceutical Sciences, 7, 21.
Khan, F., Haider, M.F., Singh, M.K., Sharma, P., Kumar, T., & Neda, E.N. (2019). Comprehensive review on kidney stones, its diagnosis and treatment with allopathic and ayurvedic medicines. Urol Nephrol Open Access J., 7(4).
Khiari, S., Boussaid, M., & Messaoud, C. (2015). Genetic diversity and population structure in natural populations of Tunisian Azarole (Crataegus azarolus L. var. aronia L.) assessed by microsatellite markers. Biochemical Systematics and Ecology, Volume 59, 264-270.
Kumar, S., & Pandey, A.K. (2013). Chemistry and biological activities of flavonoids: an overview. Scientific World Journal, doi: 10.1155/2013/162750.
Larayetan, R., Ololade, Z.S., Ogunmola, O.O., & Ladokun, A. (2019). Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon citrinus. Evidence-Based Complementary and Alternative Medicine, vol. 2019: https://doi.org/10.1155/2019/5410923.
Lien, T.H., Wu, J.S., Yang, Y.C., Sun, Z.J., & Chang, C.J. (2016). The effect of glycemic status on kidney stone disease in patients with prediabetes. Diabetes Metab J, 40(2), 161-166.
Lu, D.Y., & Lu, T.R. (2019). Herbal medicine in new era. Hospice & Palliative Medicine International Journal, 3(4), 125‒130.
Mahmud, S. A. (2017a). Optimal Extraction of Flavonoids from the Moringa olifera Seeds Extract and Study of its Antioxidant Activity. Journal of Chemical and Pharmaceutical Research, 9(4), 326-330.
Mahmud, S. A. (2017b). Green synthesis of least agglomerated highly stable silver NPs using the optimal aqueous extract of the Moringa olifera seeds. Moroccan Journal of Chemistry, 5, 708-712.
Mahmud, S. A., Khdhr, A. R., Taha, A.M., Qadir, H.A., Abdulla, P.M. et al. (2021). Effects of Allium siculum in ethylene glycol induced kidney stone in male albino rats. Kuwait Journal of Science, 48(3): https://doi.org/10.48129/kjs.v48i3.
Mahmud, S.A., Al-Habib, O.A.M., Bugoni, S., Clericuzio, M. & Vidari, G. (2016). A new ursane-type triterpenoid and other constituents from the leaves of Crataegus azarolus var. aronia. Natural Product Communications, 11: 1637.
Mahmud, S.A. (2021). Green Synthesis of Bioactive CuO@Fe3O4@Walnut Shell Nanocomposite Using Crataegus azarolus Var. aronia L. Extract and its Antivasoconstrictive Action on Rat’s Aortic Smooth Muscle. Polytechnic Journal, 11(1): 118-125.
Mahmud, S.A., & Mahmud, A.M.R. (2013). Physiological effects of melatonin on leptin, testosterone and biochemical parameters in albino rats. IOSR J. Pharm. 3(4), 48-53.
Manzoor, F., Zafar, A., & Iqbal, I. (2016). Heterotermesindicola (Wasmann) (Isoptera: Rhinotermitidae) responses to extracts from three different plants. Kuwait J. Sci, 43(3), 128-134.
Mohammed, M.T. (2015). Biochemical studies on the effect of Crataegus aqueous extract on oxidative stress during ischemia/reperfusion induced myocardial injuries. Journal of the Faculty of Medicine, 57(3), 248-253.
Moustafa, A.A., Zaghloul, M.S., Mansour, S.R., & Alotaibi, M. (2019). Conservation Strategy for protecting Crataegus x sinaica against climate change and anthropologic activities in South Sinai Mountains, Egypt. Catrina The International Journal of Environmental Science, 18 (1).
Namdari, M., Eatemadi, A., Soleimaninejad, M., & Hammed, A.T. (2017). A brief review on the application of nanoparticle enclosed herbal medicine for the treatment of infective endocarditis. Biomedicine & Pharmacotherapy, 87, 321-331.
Nazhand, A., Lucarini M., Durazzo A., Zaccardelli M., Cristarella S., Souto S.B., Silva A.M., Severino P., Souto E.B., & Santini A. (2020). Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties. Forests, 11, 564.
Rjeibi, I., Feriani A., Hentati F., Hfaiedh N., Michaud P., & Pierre G. (2019). “Structural characterization of water-soluble polysaccharides from Nitraria retusa fruits and their antioxidant and hypolipidemic activities.” International Journal of Biological Macromolecules, 129, 422–432.
Rjeibi, I., Zaabi, R., & Jouida, W. (2020). Characterization of Polysaccharides Extracted from Pulps and Seeds of Crataegus azarolus L. var. aronia: Preliminary Structure, Antioxidant, Antibacterial, α-Amylase, and Acetylcholinesterase Inhibition Properties. Hindawi Oxidative Medicine and Cellular Longevity, Volume 2020.
Saad, B., Azaizeh, H., & Said, O. (2005). "Tradition and Perspectives of Arab Herbal Medicine: A Review." Evidence-Based Complementary and Alternative Medicine. 2(4), 475-479.
Sammari, H., Jedidi, S., Selmi, H., Rtibi, K., Jabri, M.A., Jridi, M., Zouari, N., Toumi, L., & Sebai, H. (2021). Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil-induced diarrhea, oxidative stress, and inflammation in rat. Neurogastroenterol Motil, 33(6): e14065. doi: 10.1111/nmo.
Sagaradze, V.A., Babaeva, E.Y., Ufimov, R.A., Trusov, N.A., & Kalenikova, E.I. (2019). Study of the variability of rutin, vitexin, hyperoside, quercetin in “Crataegi folium cum flore” of hawthorn (Crataegus L.) species from Russian flora. Journal of Applied Research on Medicinal and Aromatic Plants, Volume 15.
Sharma, I., Khan, W., Parveen, R., Alam, Md.J., Ahmad, I., Ansari, M.H.R., & Ahmad, S. (2017). "Antiurolithiasis Activity of Bioactivity Guided Fraction of Bergenia ligulata against Ethylene Glycol Induced Renal Calculi in Rat". BioMed Research International, vol. 2017, Article ID 1969525, 11 pages. https://doi.org/10.1155/2017/1969525.
Shekha, M.S., Ismail, T.F., & Aziz, F.M. (2015). Anti-urolithiatic and anti-oxidant effects of fenugreek on ethylene glycol-induced kidney calculi in rats. JJBS, 159-163.
Shirfule, A.L., Sangamwar, A.T., & Khobragade, C.N. (2011). “Exploring glycolate oxidase (GOX) as an antiurolithic drug target: Molecular Modeling and In Vitro Inhibitor Study.” International Journal of Biological Macromolecules, 49(1) 62–70.
Shukla, A.K., Shukla, S., Garg, A., Garg, S., & Sukhadia, M. (2017). A Review on Anti-Urolithiatic Activity Of Herbal Folk Plants. Asian Journal of Biomaterial Research, 3(2), 1-11.
Wang, J., Yan, Z., Zhou, L., Huang, X., & Song, S. (2018). The genus Crataegus: a review of phytochemistry and pharmacology perspectives. Asian Journal of Traditional Medicines, 13(5), 200-213. 14p.
Yahyaoui, A., Arfaoui, M.O., Rigane, G., Hkir, A., Amari, K., Salem, R.B., & Ammari, Y. (2019). “Investigation on the chemical composition and antioxidant capacity of extracts from Crataegus azarolus L.: effect of growing location of an important Tunisian medicinal plant,” Chemistry Africa, 2(3), 361–365.
Zeni, A.L.B., Moreira, T.D., Dalmagro, A.P., Camargo, A., Bini, L.A., et al. (2017). Evaluation of phenolic compounds and lipidlowering effect of Morus nigra leaves extract. Anais da Academia Brasileira de Ciências, 89(4), 2805–2815.
Zhang, J., Onakpoya, I.J., Posadzki, P., & Eddouks, M. (2015). The Safety of Herbal Medicine: From Prejudice to Evidence. Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine, Volume 2015.
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