PROTECTIVE ROLES OF Lactuca serriola AND Glycyrrhiza glabra ON ETHYLENE GLYCOL INDUCED UROLITHIASIS IN MALE ALBINO RATS (Rattus norvegicus)

Authors

  • Sarbast A. Mahmud Department of Biology, Faculty of Science, Soran University, Soran, Kurdistan Region, Iraq
  • Imad T. Abdulla Department of Biology, College of Science, University of Zakho, Duhok, Kurdistan Region, Iraq
  • Aveen R. Khdhr Department of Biology, Faculty of Science, Soran University, Soran, Kurdistan Region, Iraq
  • Khalid Q. Gardi Department of Urology, Rizgari Teaching Hospital, Ministry of Health, Erbil, Kurdistan Region, Iraq

DOI:

https://doi.org/10.25271/sjuoz.2025.13.3.1494

Keywords:

Ethylene Glycol, Glycyrrhiza glabra, Histology of Kidneys, Lactuca serriola, Renal Calculi

Abstract

This study aimed to evaluate the protective effects of Lactuca serriola (L. serriola) and Glycyrrhiza glabra (G. glabra) against ethylene glycol (EG)-induced urolithiasis in male albino rats. Twenty-eight rats were divided into four groups: control, EG-treated, and two groups co-administered with L. serriola or G. glabra alongside EG. Body weight, food and water intake, kidney and liver function, serum electrolytes, and lipid profiles were assessed. Histological examination and urine crystal analysis were also performed. Co-administration of L. serriola and G. glabra protected against EG-induced increases in serum creatinine, urea, and glutamic oxaloacetic transaminase (GOT) levels. Lactuca serriola also prevented triglyceride (TG) elevation, while G. glabra effectively maintained food intake. Both herbs significantly reduced the kidney weight increase, crystal formation, and tissue damage. Histological analysis showed reduced calcium oxalate (CaOx) crystal deposition and tissue injury with herb supplementation. In conclusion, L. serriola and G. glabra demonstrated protective roles against urolithiasis and may serve as potential natural anti-urolithiasis agents

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Published

2025-07-03

How to Cite

Mahmud, S. A., Abdulla, I. T., Khdhr, A. R., & Gardi, K. Q. (2025). PROTECTIVE ROLES OF Lactuca serriola AND Glycyrrhiza glabra ON ETHYLENE GLYCOL INDUCED UROLITHIASIS IN MALE ALBINO RATS (Rattus norvegicus). Science Journal of University of Zakho, 13(3), 357–366. https://doi.org/10.25271/sjuoz.2025.13.3.1494

Issue

Vol. 13 No. 3 (2025): July-September issue

Section

Science Journal of University of Zakho

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Copyright (c) 2025 Sarbast A. Mahmud, Imad T. Abdulla, Aveen R. Khdhr, Khalid Q. Gardi

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