Vasorelaxant and Antispasmodic Effects of Some Polyphenols and Glycoside in Rat Smooth Muscles

  • Mudhir S. Shekha University of Salahaddin
Keywords: vasorelaxant, antispasmodic, polyphenol, glycoside, rat, smooth muscles

Abstract

Objective: The present study was undertaken to investigate the effect of Luteolin, chlorogenic acid, amygdalin and tannic acid on vascular smooth muscle contractility.

Materials and Methods: The effect of different concentrations of some polyphenols and glycosides on contractile responses of isolated aorta, ileum and trachea to Acetylcholine, KCl and phenylephrine (PE) were evaluated.

Results: The results of the current study indicated that luteolin and chlorogenic acid has potent relaxant effects on KCl and PE-induced contractions in rat’s aortic ring. Amygdalin and tannic acid reduced ACh-induced ileum contractions significantly. Conclusions: The inhibitory effect of luteolin and chlorogenic acid on the contraction induced by PE and KCl may be due to their anti-adrenergic and anti-hyperpolarizing effect.

Author Biography

Mudhir S. Shekha, University of Salahaddin

Department of Biology, Colleges of Science, University of Salahaddin, Kurdistan Region – Iraq.

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Published
2014-12-30
How to Cite
Shekha, M. (2014). Vasorelaxant and Antispasmodic Effects of Some Polyphenols and Glycoside in Rat Smooth Muscles. Science Journal of University of Zakho, 2(2), 220-227. Retrieved from https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/177
Section
Science Journal of University of Zakho