Relaxant Effects of Rutin on Rat Smooth Muscles

  • Mudhir S. Shekha University of Salahaddin
  • Omar A.M Al-Habib University of Zakho
Keywords: relaxant, aorta, Ileum, Trachea, Rutin


The aim of the present study was to investigate the relaxant effects of rutin on rat thoracic aorta, ileum and trachea. Rutin (1X10-7 - 6X10-3 M) caused a concentration-dependent relaxation of aortic rings precontracted with phenylephrine (PE 10-6M) while produced non-significant relaxed effect on KCl induced contraction with Log IC50’s -3.025 and -2.885 M/ml respectively. Rutin exhibited potent inhibitory effects on (ACh  10-6 M) precontracted ileum of the rat with Log IC50 -5.996 M/mL. Rutin produced more potent inhibitory effect on ACh- than KCl-induced contractions in trachea, with Log IC50’s of -4.371 and -4.301 M/mL respectively. While rutin showed more potent inhibitory effect on PE-induced contractions potently than KCl precontracted aorta with Log IC50’s was -3.025 M and  -2.885 respectively. From the data obtained during the present work, it can be concluded that rutin induces concentration-dependent relaxation in rat's smooth muscle. The mechanism of the relaxation may involves via nitric oxide-guanylyl cyclase pathway  for aorta and anticholinergic activity for ileum and trachea.

Author Biographies

Mudhir S. Shekha, University of Salahaddin

Dept. of Biology, Colleges of Science, University of Salahaddin, Kurdistan Region-

Omar A.M Al-Habib, University of Zakho

Dept. of Biology, Faculty of Science, University of Zakho, Kurdistan Region-Iraq


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How to Cite
Shekha, M., & Al-Habib, O. (2013). Relaxant Effects of Rutin on Rat Smooth Muscles. Science Journal of University of Zakho, 1(2), 543-548. Retrieved from
Science Journal of University of Zakho