Curative Effects of Pomegranate and Ginger on Hepatic and Renal Functions of Indomethacin-Induced Peptic Ulcers in Albino Rats

Authors

  • Mudhir S. Shekha Salahaddin University
  • Muhsin J. Abdulwahid Salahaddin University
  • Peshraw S. Hamadamin Salahaddin University
  • Trifa F. Ismail Salahaddin University
  • Saman R. Hamad Bakir Erbil Directorate General of Health, Ministry of Health.
  • Laween M. Ibrahim Erbil Directorate General of Health, Ministry of Health
  • Lana M. Ahmed Salahaddin University

DOI:

https://doi.org/10.25271/2017.5.1.300

Keywords:

Peptic ulcer, Ginger, indomethacin, hepatic and renal functions, rats

Abstract

A peptic ulcer is one of the more severe diseases and most classic treatment protocol produce adverse drug reactions. Therefore, this study aimed to examine the therapeutic effects of two natural extracts, namely Pomegranate and Ginger, on indomethacin-induced gastric ulcer in rats. Animals were divided into five groups; 1. Normal control group, 2. An ulcer control group Indomethacin (0.3 mg /rats), 3. Omeprazole (3 mg /rats), a4. Pomegranate (40 mg /rats), 5. Ginger (20 mg /rats).  The ulcers were induced made from groups 2 - 5 by oral administration of Indomethacin. Rats subjected to indomethacin administration showed significant ulceration in the glandular area of their stomachs compared to normal control rats. In addition, significant elevations S.GPT, S.GOT, S. creatinine and S. Urea (P< 0.05) were observed. Alternatively, pretreatment with pomegranate and ginger significantly corrected macroscopic and biochemical parameters. These results demonstrate that administration of either pomegranate and ginger supplementation have an essential role in the prevention of ulceration induced by NSAIDs. Furthermore improved liver and kidney functions and reduced hepatoto and nephrotoxicities.

Author Biographies

Mudhir S. Shekha, Salahaddin University

Dept. of Biology, College of Science, University of Salahaddin, Kurdistan Region - Iraq.

Muhsin J. Abdulwahid, Salahaddin University

Research Center, University of Salahaddin, Erbil, Kurdistan Region - Iraq.

Peshraw S. Hamadamin, Salahaddin University

Dept. of Biology, College of Science, University of Salahaddin, Kurdistan Region - Iraq.

Trifa F. Ismail, Salahaddin University

Dept. of Biology, College of Education, Salahaddin University, Kurdistan Region - Iraq.

Saman R. Hamad Bakir, Erbil Directorate General of Health, Ministry of Health.

Hareer Hospital, Erbil Directorate General of Health, Ministry of Health, Kurdistan Region - Iraq.

Laween M. Ibrahim, Erbil Directorate General of Health, Ministry of Health

Rapareen Children Hospital, Erbil Directorate General of Health, Ministry of Health, Kurdistan Region - Iraq.

Lana M. Ahmed, Salahaddin University

Dept. of Biology, College of Science, University of Salahaddin, Kurdistan Region - Iraq.

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Published

2017-03-30

How to Cite

Shekha, M. S., Abdulwahid, M. J., Hamadamin, P. S., Ismail, T. F., Hamad Bakir, S. R., Ibrahim, L. M., & Ahmed, L. M. (2017). Curative Effects of Pomegranate and Ginger on Hepatic and Renal Functions of Indomethacin-Induced Peptic Ulcers in Albino Rats. Science Journal of University of Zakho, 5(1), 48–52. https://doi.org/10.25271/2017.5.1.300

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Section

Science Journal of University of Zakho