Studying the Association Between Systolic Blood Pressure and Thyroid Stimulating Hormone in Newly Diagnosed Subclinical Hyperthyroidism Female Patients

Authors

  • Mohammed Abdulwahid Hami Dept. of Chemistry, Faculty of Science, University of Zakho, Zakho, Kurdistan Region, Iraq
  • Kazheen Hussein Jawzal Dept. of Chemistry, Faculty of Science, University of Zakho, Zakho, Kurdistan Region, Iraq
  • Lina Yousif Mohammed Dept of Biomedical Science, College of Medicine, University of Zakho, Zakho, Iraq
  • Aveen Akram Ibrahiem Dept of Biomedical Science, College of Medicine, University of Zakho, Zakho, Iraq

DOI:

https://doi.org/10.25271/sjuoz.2022.10.4.969

Keywords:

Subclinical hyperthyroidism, Dyslipidemia, Thyroid, Hormone, Blood pressure.

Abstract

Background: Subclinical hyperthyroidism is a condition in which thyroid stimulating hormone (TSH) is mildly decreased with both free iodine thyroxine (free T4) and triiodothyronine (T3) within the normal range. The aim of this research is to determine the association between TSH with lipid profiles, age, blood pressure and body mass index (BMI) and also to evaluate lipid profiles in subclinical hyperthyroid patients.

Materials and Methods: Ninety patients with subclinical hyperthyroidism were chosen as the patient group and 50 healthy individuals age-matched were chosen as the control group. Thyroid function tests TSH, T4 and T3 were performed by VIDAS and on the same day lipid profiles were performed by (Biolis 24i Premium) in the laboratory of General Zakho Hospital, Kurdistan Region, Iraq.

Results: In subclinical hyperthyroidism the BMI and diastolic blood pressure values were non-significantly low (P=0.13 and p=0.27 respectively) whereas systolic blood pressure increased slightly but was still non-significant. TSH was significantly and negatively related to systolic blood pressure.

Conclusion: Lipid profiles and systolic and diastolic blood pressure are not altered in subclinical hyperthyroidism. However, systolic blood pressure is related to the severity of the decrease in TSH levels.

Author Biographies

Mohammed Abdulwahid Hami, Dept. of Chemistry, Faculty of Science, University of Zakho, Zakho, Kurdistan Region, Iraq

Dept. of Chemistry, Faculty of Science, University of Zakho, Zakho, Kurdistan Region, Iraq (mohammed.hami@uoz.edu.krd)

Kazheen Hussein Jawzal, Dept. of Chemistry, Faculty of Science, University of Zakho, Zakho, Kurdistan Region, Iraq

Dept. of Chemistry, Faculty of Science, University of Zakho, Zakho, Kurdistan Region, Iraq (kazheen.jawzal@uoz.edu.krd)

Lina Yousif Mohammed, Dept of Biomedical Science, College of Medicine, University of Zakho, Zakho, Iraq

Dept of Biomedical Science, College of Medicine, University of Zakho, Zakho, Iraq (lina.mohammed@uoz.edu.krd)

Aveen Akram Ibrahiem, Dept of Biomedical Science, College of Medicine, University of Zakho, Zakho, Iraq

Dept of Biomedical Science, College of Medicine, University of Zakho, Zakho, Iraq (aveen.ibrahem@uoz.edu.krd)

References

Bel Lassen, P., Kyrilli, A., Lytrivi, M., Ruiz Patino, M., Corvilain, B., 2017. Total thyroidectomy: a clue to understanding the metabolic changes induced by subclinical hyperthyroidism? Clin Endocrinol (Oxf) 86, 270–277. https://doi.org/10.1111/cen.13237

Biondi, B., 2021. “Is there any reason to treat subclinical hypo and hyperthyroidism?” Ann Endocrinol (Paris) 82, 161–162. https://doi.org/10.1016/j.ando.2020.03.003

Biondi, B., Palmieri, A., Klain, M., Schlumberger, M., Filetti, S., Lombardi, G., 2005. Subclinical hyperthyroidism: Clinical features and treatment options. Eur J Endocrinol 152(1), 1-9, https://doi.org/10.1530/eje.1.01809

Das, G., Ojewuyi, T.A., Baglioni, P., Geen, J., Premawardhana, L.D., Okosieme, O.E., 2012. Serum thyrotrophin at baseline predicts the natural course of subclinical hyperthyroidism. Clin Endocrinol (Oxf) 77, 146–151. https://doi.org/10.1111/j.1365-2265.2012.04345.x

Erem, C., Suleyman, A.K., Ci̇ Van 1), N., Mentese, A., Nuhoglu, İ., Uzun, A., Onder Ersoz, H., Deger, O., 2015. Ischemia-modified albümin and malondialdehyde levels in patients with overt and subclinical hyperthyroidism: effects of treatment on oxidative stress. Endocr J. https://doi.org/10.1507/endocrj

Family, A., Donangelo, I., Braunstein, G.D., 2011. Update on Subclinical Hyperthyroidism. American family physician, 83(8), pp.933-938.

Hami, M.A., Al-Tamer, Y.A., AL-Hebib, O.M., 2020. The association between selected elements and body mass index and age in male subjects. Trace Elements and Electrolytes 37. https://doi.org/10.5414/tex01613

Heemstra, K.A., Smit, J.W.A., Eustatia-Rutten, C.F.A., Heijboer, A.C., Frölich, M., Romijn, J.A., Corssmit, E.P.M., 2006. Glucose tolerance and lipid profile in longterm exogenous subclinical hyperthyroidism and the effects of restoration of euthyroidism, a randomised controlled trial. Clin Endocrinol (Oxf) 65, 737–744. https://doi.org/10.1111/j.1365-2265.2006.02660.x

Iqbal, M.A., Ahmad, S., Mumtaz, T., Naseem, Z., Malik, J., Ahmad, H., Roohi, N., 2021. Prospective Analysis of Lipid Variations in Hyperthyroid Subjects from Lahore, Pakistan. Biomed Res Int 2021, 1–9. https://doi.org/10.1155/2021/9936782.

Jawzal, K. et al. (2022) ‘The relationship between thyroid hormones and lipid profile in subclinical hypothyroidism female patients’, Baghdad Journal of Biochemistry and Applied Biological Sciences, 3(03), pp. 200–209.

Jung, K.Y., Ahn, H.Y., Han, S.K., Park, Y.J., Cho, B.Y., Moon, M.K., 2017. Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function. J Clin Lipidol 11, 1347–1353. https://doi.org/10.1016/j.jacl.2017.08.015

Kamiński, G.W., Makowski, K., Michalkiewicz, D., Kowal, J., Ruchala, M., Szczepanek, E., Gielerak, G., 2012. The influence of subclinical hyperthyroidism on blood pressure, heart rate variability and incidence of arrhythmia. Thyroid. https://doi.org/10.1089/thy.2010-0333

Kotwal, A., Cortes, T., Genere, N., Hamidi, O., Jasim, S., Newman, C.B., Prokop, L.J., Hassan Murad, M., Alahdab, F., 2020. Treatment of thyroid dysfunction and serum lipids: A systematic review and meta-analysis. Journal of Clinical Endocrinology and Metabolism 105, 3683–3694. https://doi.org/10.1210/clinem/dgaa672

Links, T.P., van der Boom, T., Zandee, W.T., Lefrandt, J.D., 2021. Cardiovascular effects of overt and subclinical hyperthyroidism: Focus on differentiated thyroid cancer. Endocr Connect, 10(1),pp.43-51. https://doi.org/10.1530/EC-20-0539

Maratou, E., Hadjidakis, D.J., Peppa, M., Alevizaki, M., Tsegka, K., Lambadiari, V., Mitrou, P., Boutati, E., Kollias, A., Economopoulos, T., Raptis, S.A., Dimitriadis, G., 2010. Studies of insulin resistance in patients with clinical and subclinical hyperthyroidism. Eur J Endocrinol 163, 625–630. https://doi.org/10.1530/EJE-10-0246

Peppa, M., Betsi, G., Dimitriadis, G., 2011. Lipid Abnormalities and Cardiometabolic Risk in Patients with Overt and Subclinical Thyroid Disease. J Lipids 2011, 1–9. https://doi.org/10.1155/2011/575840

Rizos, C. v, Liberopoulos, E.N., 2011. Effects of Thyroid Dysfunction on Lipid Profile, The Open Cardiovascular Medicine Journal, 5 p.76.

Rudzki, G., Lenart-Lipińska, M., Smoleń, A., Chrapko, B.E., Matyjaszek-Matuszek, B., 2019. Subclinical hyperthyroidism in the course of autonomous nodules — clinical evaluation. Endokrynol Pol 70, 157–164. https://doi.org/10.5603/EP.a2018.0088

Soni, N., Kaushik, G.G., 2014. To study glycemic status and lipid fractions in subclinical hypothyroid, overt hypothyroid and hypothyroid subjects, International Journal of Advanced Research, 2(9), pp.761-767.

Tribulova, N., Kurahara, L.H., Hlivak, P., Hirano, K., Bacova, B.S., 2020. Pro-arrhythmic signaling of thyroid hormones and its relevance in subclinical hyperthyroidism. Int J Mol Sci, 21(8), p.2844. https://doi.org/10.3390/ijms21082844

Völzke, H., Alte, D., Dö Rr B, M., Wallaschofski, H., John, U., Felix, S.B., Rettig, R., 2006. The association between subclinical hyperthyroidism and blood pressure in a population-based study, Journal of Hypertension, 24(10), pp.1947-1953.

Walsh, J.P., Bremner, A.P., Bulsara, M.K., O’Leary, P., Leedman, P.J., Feddema, P., Michelangeli, V., 2006. Subclinical thyroid dysfunction and blood pressure: A community-based study. Clin Endocrinol (Oxf) 65, 486–491. https://doi.org/10.1111/j.1365-2265.2006.02619.x

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Published

2022-11-07

How to Cite

Hami, M. A., Jawzal, K. H., Mohammed, L. Y., & Ibrahiem, A. A. (2022). Studying the Association Between Systolic Blood Pressure and Thyroid Stimulating Hormone in Newly Diagnosed Subclinical Hyperthyroidism Female Patients. Science Journal of University of Zakho, 10(4), 197–200. https://doi.org/10.25271/sjuoz.2022.10.4.969

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Science Journal of University of Zakho