Synthesis of Functionalized 4-Aryl-2,3 Bis (Trifluoromethanesulfonyloxy) Benzophenones, Based on Site-Selective Suzuki-Miyaura Cross-Coupling Reactions of 2,3,4-Tris (Trifluoromethanesulfonyloxy) Benzophenone.

  • Nadi Eleya University of Zakho
Keywords: benzophenones, Cross-coupling, Palladium, Regioselectivity

Abstract

Suzuki–Miyaura reactions of the tris(triflate) of 2,3,4-benzophenonewith one 1 equivalent of arylboronic acids afforded 4-aryal-2,3-  bis(trifluoromethanesulfonyloxy)benzophenones with very good site selectivity favor of position C4 which is satirically less hindered than position C2.

Author Biography

Nadi Eleya, University of Zakho

Department Of Chemistry, Collage Of Science, Zakho University,Kurdistan – region, Iraq.

References

Barder, T. E.; Walker, S. D.; Martinelli, J. R.; Buchwald, S. L. J. Am. Chem.Soc. 2005, 127, 4685.
Baxter, J.; Steinhuebel, D.; Palucki, M.; Davies, I. W. Org. Lett. 2005, 7, 215.
Cai, X.; Sakamoto, M.; Fujitsuka, M.; Majima, T. Chem. Eur. J. 2005, 11, 6471.
De-Souza, A. O.; Santos, R. R.; Melo, P. S.; Alderete, J. B.; Conti, R. De; Haun, M.; Sato, D. N.; Duran, N. Pharmazie2001, 56, 871.
Geissler, H.In Tranasition Metals for Organic Synthesis; Beller, M. Bolm, C., Eds.; Wiley-VCH: Weinheim, 1998.uran, N. Pharmazie2001, 56, 871.
Hassan, J.; Se´ vignon, M.; Gozzi, C.; Schulz, E.; Lemaire, M. Chem. Rev. 2002, 102, 1359–1469.
Kingston, J. V.; Verkade, J. G. J. Org. Chem. 2007, 72, 2816.
Li, J.; Zhang, Y.; Song, R.;Xie, Y.; Deng, C.; Liang, Y. Synthesis2007, 2957–2966.
Miyaura, N.; Suzuki, A. J. Chem. Soc., Chem. Commun.1979, 19, 866.
Miyaura, N.; Suzuki, A. Chem. Rev. 1995, 95, 2457–2483
Nakano, Y.; Imai, D. Synthesis1997, 1425–1428
Szuki, A.In Metal-catalyzed Cross-coupling Reactions; 1ed. Diederich, F., Stang, P.j., Eds.; Wiley-VCH: Weinheim, 1998.
Zhang, H.; Kwong, F. Y.; Tian, Y.; Chan, K. S. J. Org. Chem. 1998, 63, 6886–6890.
Published
2013-06-30
How to Cite
Eleya, N. (2013). Synthesis of Functionalized 4-Aryl-2,3 Bis (Trifluoromethanesulfonyloxy) Benzophenones, Based on Site-Selective Suzuki-Miyaura Cross-Coupling Reactions of 2,3,4-Tris (Trifluoromethanesulfonyloxy) Benzophenone. Science Journal of University of Zakho, 1(1), 300-307. Retrieved from https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/94
Section
Science Journal of University of Zakho