Synthesis and Spectroscopic Identification Of A New Series Of Biologically Active 2-Iminothiazolidine-4-One Derivatives

Authors

  • Hashim J. Azeez University of Salahaddin
  • Venos S. Abdulla University of Salahaddin

Keywords:

iminothiazolidin-4-one, antimicrobial, addition–elimination

Abstract

A series of 2-amino-5-(substituted phenyl) 1,3,4- thiadiazol have been synthesized through the reaction of  thiosemicarbazide with substituted  benzoic acids in the presence of phosphoroxy chloride readily undergo  nucleophilic addition – elimination reaction with chloroacetyl chloride in benzene as a solvent to afford 2-chloro acetamido compounds. The prepared compounds were subjected  cyclization reaction and results in the formation of a series of 2- imino-3-(substituted phenyl)  1,3,4- thiadiazol-2yl-thiazolidinone -4 one .  The IR ,1H and 13C- NMR spectra of the prepared compounds were confirmed to their proposed structures . Finally antimicrobial activity of the newly obtained compounds were tested against Klepsilla pneumonia (gram -ve )     and  Staphylococcusaurous (gram + ve)  and the results showed that most of the prepared compounds are sensitive against both types of test organisms in different activities .

Author Biographies

Hashim J. Azeez, University of Salahaddin

Department of Chemistry, College of Education, University of Salahaddin, Kurdistan Region-Iraq.

Venos S. Abdulla, University of Salahaddin

Department of Chemistry, College of Education, University of Salahaddin, Kurdistan Region-Iraq.

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Published

2014-06-30

How to Cite

Azeez, H. J., & Abdulla, V. S. (2014). Synthesis and Spectroscopic Identification Of A New Series Of Biologically Active 2-Iminothiazolidine-4-One Derivatives. Science Journal of University of Zakho, 2(1), 156–165. Retrieved from https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/136

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Science Journal of University of Zakho