Human Scalp Hair Follicles Express Prostaglandin E2 Lipid Mediator and Receptors For Pge2

  • Karzan G. Khidhir University of Sulaimani
Keywords: Alopecia, Hair Follicle, Immunohistochemistry, Lipidomics, Prostaglandin E2 receptor, RT-PCR

Abstract

The hair follicle, which is a unique characteristic of the mammals, plays a vital role in a personal appearance and self-image confidence throughout the life and hair growth disorders cause serious psychological distress. The common pathological abnormalities are abnormal hair loss (alopecia) and excessive hair growth (hirsutism), but they are poorly controlled. Therefore an improved treatment for these disorders requires a better understanding of the mechanisms regulating hair growth. Prostaglandin analogues such as latanoprost, which are used for glaucoma treatment, also makes eyelashes grow longer. The mechanism of action by which these drugs stimulate eyelash hair growth is poorly understood. To determine whether PGE2 lipid mediator and receptors for PGE2 (EP2) are expressed in scalp hair follicle, electrospray tandem mass spectrometry coupled to liquid chromatography (LC/ESI-MS/MS), RT-PCR and Immunohistochemistry were carried out. Human scalp skin from non-balding areas (occipital and parietal) was obtained from healthy donors undergoing elective cosmetic surgery; with appropriate ethical approval. Isolated scalp hair follicle expresses PGE2 lipid mediator genes and protein for EP2. So isolated human scalp follicles contain PGE2 lipid mediator and express genes and protein for EPindicating that PGEmay play a vital role in regulating hair growthwhich may lead to a new method for hair loss treatment.  

Author Biography

Karzan G. Khidhir, University of Sulaimani

Department of Biology, Faculty of Science, University of Sulaimani, Sulaimani, Kurdistan Region-Iraq.

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Published
2013-09-30
How to Cite
Khidhir, K. (2013). Human Scalp Hair Follicles Express Prostaglandin E2 Lipid Mediator and Receptors For Pge2. Science Journal of University of Zakho, 1(2), 533-542. Retrieved from https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/263
Section
Science Journal of University of Zakho