Helicobacter pylori Seropositivity in Children in Duhok City, Iraq

  • Nizar B. Yahya University of Duhok
Keywords: Helicobacter pylori, pediatric, children, Duhok, Iraq


Introduction: Helicobacter pylori(H. pylori) is a gram negative bacteria that causes gastritis and peptic ulcer disease (PUD). It is widely accepted that the infection may occur early in life and may persist for decades before causing diseases. The aim of this paper was to determine the prevalence of H. pyloriseropositivity in pediatric age group and to examine the associated risk factors. Patients and methods: Blood samples were collected from 100 subjects attending Hevi Pediatric Teaching Hospital over a period of 6 months and IgG positivity was determined. A questionnaire sheet was prepared and used for each study subject. Data were collected by a face-to-face interview.Results: It was found that 28/100 (28%) of the recruited sample was positive for H. pyloriseropositivity. A significant association was found between the number of siblings and H. pyloripositivity (P=0.01, OR=1.3). No significant relationships were found between other factors and H. pyloripositivity. Conclusions: The prevalence of H. pyloriinfection was less than that reported in the city previously and less than that reported in neighboring countries. A significant positive association was found between number siblings and H. pyloriinfection rate. Further studies are needed recruiting larger sample size to explore H. pyloriprevalence and its associated risk factors.

Author Biography

Nizar B. Yahya, University of Duhok

Department of Pediatric, College of Medicine, University of Duhok, Kurdistan Region, Iraq.


Arslan, E., H. Atligan and A. Yavasoglu (2009). "The prevalence of Helicobacter pylori in obese subjects." European Journal of Internal Medicine 20(7): 695-697.10.1016/j.ejim.2009.07.013: 10.1016/j.ejim.2009.07.013
Atherton, J. C. (2006). "THE PATHOGENESIS OF HELICOBACTER PYLORI INDUCED GASTRO-DUODENAL DISEASES." Annual Review of Pathology: Mechanisms of Disease 1(1): 63-96.10.1146/annurev.pathol.1.110304.100125: 10.1146/annurev.pathol.1.110304.100125
Choi, J. S., K. O. Ko, J. W. Lim, E. J. Cheon, G. M. Lee and J. M. Yoon (2016). "The Association between Helicobacter pylori Infection and Body Weight among Children." Pediatric Gastroenterology, Hepatology & Nutrition 19(2): 110-115.10.5223/pghn.2016.19.2.110: 10.5223/pghn.2016.19.2.110
Dore, M. P., H. M. Malaty, D. Y. Graham, G. Fanciulli, G. Delitala and G. Realdi (2002). "Risk Factors Associated with Helicobacter pylori Infection among Children in a Defined Geographic Area." Clinical Infectious Diseases 35(3): 240-245
Falsafi, T., N. Valizadeh, S. Sepehr and M. Najafi (2005). "Application of a Stool Antigen Test To Evaluate the Incidence of Helicobacter pylori Infection in Children and Adolescents from Tehran, Iran." Clinical and Diagnostic Laboratory Immunology 12(9): 1094-1097.10.1128/cdli.12.9.1094-1097.2005: 10.1128/cdli.12.9.1094-1097.2005
Fialho, A. M. N., A. B. C. Braga, M. B. Braga Neto, J. G. Carneiro, A. M. C. Rocha, M. N. Rodrigues, D. M. M. Queiroz and L. L. B. C. Braga (2010). "Younger Siblings Play a Major Role in Helicobacter pylori Transmission Among Children From a Low-Income Community in the Northeast of Brazil." Helicobacter 15(6): 491-496.10.1111/j.1523-5378.2010.00791.x: 10.1111/j.1523-5378.2010.00791.x
Hasosah, M., M. Satti, A. Shehzad, A. Alsahafi, G. Sukkar, A. Alzaben, A. Sunaid, A. Ahmed, S. AlThubiti, A. Mufti and K. Jacobson (2015). "Prevalence and Risk Factors of Helicobacter pylori Infection in Saudi Children: A Three-Year Prospective Controlled Study." Helicobacter 20(1): 56-63.10.1111/hel.12172: 10.1111/hel.12172
Hussein Nawfal, R., K. Robinson and C. Atherton John (2008). "A study of Age Specific Helicobacter pylori Seropositivity Rates in Iraq." Helicobacter 13(4): 306-307.10.1111/j.1523-5378.2008.00618.x: 10.1111/j.1523-5378.2008.00618.x
Hussein, N. R. (2010). "Helicobacter pylori and gastric cancer in the Middle East: A new enigma?" World Journal of Gastroenterology : WJG 16(26): 3226-3234.10.3748/wjg.v16.i26.3226: 10.3748/wjg.v16.i26.3226
Hussein, N. R., M. Mohammadi, Y. Talebkhan, M. Doraghi, D. P. Letley, M. K. Muhammad, R. H. Argent and J. C. Atherton (2008). "Differences in Virulence Markers between Helicobacter pylori Strains from Iraq and Those from Iran: Potential Importance of Regional Differences in H. pylori-Associated Disease." Journal of Clinical Microbiology 46(5): 1774-1779.10.1128/jcm.01737-07: 10.1128/jcm.01737-07
Hussein, N. R., Z. S. M. Saleem, A. A. Balatay, K. H. Abd, S. Daniel, A. A. Taha, N. M. R. Ibrahim and M. S. Assafi (2016). "Seroprevalence of Helicobacter pylori Infection in Renal Transplant Recipient Attending Duhok Kidney Disease Center." Transplantation Proceedings 48(1): 92-95.10.1016/j.transproceed.2016.01.006: 10.1016/j.transproceed.2016.01.006
Ioannou, G. N., N. S. Weiss and D. J. Kearney (2005). "Is Helicobacter pylori seropositivity related to body mass index in the United States?" Alimentary Pharmacology & Therapeutics 21(6): 765-772.10.1111/j.1365-2036.2005.02369.x: 10.1111/j.1365-2036.2005.02369.x
Malaty, H. M., V. Paykov, O. Bykova, A. Ross, D. P. Graham, J. F. Anneger and D. Y. Graham (1996). "Helicobacter pylori and Socioeconomic Factors in Russia." Helicobacter 1(2): 82-87.10.1111/j.1523-5378.1996.tb00015.x: 10.1111/j.1523-5378.1996.tb00015.x
Marcela, K., J. BureÅ¡, I. Koupil, S. Rejchrt, V. Viktor, B. Seifert, O. i. Pozler, P. Živný, T. Å. Douda, V. Palicka, J. Holcik and G. the European Society for Primary Care (2007). "Body indices and basic vital signs in Helicobacter pylori positive and negative persons." European Journal of Epidemiology 22(1): 67-75.10.1007/s10654-006-9090-1: 10.1007/s10654-006-9090-1
Muhsen, K. H., A. Athamna, M. Athamna, A. Spungin-Bialik and D. Cohen (2006). "Prevalence and risk factors of Helicobacter pylori infection among healthy 3- to 5-year-old Israeli Arab children." Epidemiology and Infection 134(5): 990-996.10.1017/s0950268806006030: 10.1017/s0950268806006030
Osaki, T., M. Konno, H. Yonezawa, F. Hojo, C. Zaman, M. Takahashi, S. Fujiwara and S. Kamiya (2015). "Analysis of intra-familial transmission of Helicobacter pylori in Japanese families." Journal of Medical Microbiology 64(1): 67-73.doi:10.1099/jmm.0.080507-0: doi:10.1099/jmm.0.080507-0
Ozbey, G., Y. Dogan, K. Demiroren and I. H. Ozercan (2015). "Prevalence of Helicobacter pylori in children in eastern Turkey and molecular typing of isolates." Brazilian Journal of Microbiology 46(2): 505-511.10.1590/s1517-838246220140234: 10.1590/s1517-838246220140234
Santos, I. S., J. Boccio, L. Davidsson, M. Hernandez-Triana, E. Huanca-Sardinas, M. Janjetic, S. Y. Moya-Camarena, M. C. Paez-Valery, V. Ruiz-Alvarez, M. E. Valencia, N. C. J. Valle, G. Vargas-Pinto, L. Solano and J. Thomas (2009). "Helicobacter pylori is not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela." Public Health Nutrition 12(10): 1862-1870.Doi: 10.1017/s1368980009004789: Doi: 10.1017/s1368980009004789
Soltani, J., J. Amirzadeh, S. Nahedi and S. Shahsavari (2013). "Prevalence of Helicobacter Pylori Infection in Children, a Population-Based Cross-Sectional Study in West Iran." Iranian Journal of Pediatrics 23(1): 13-18
Wroblewski, L. E., R. M. Peek and K. T. Wilson (2010). "Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk." Clinical Microbiology Reviews 23(4): 713-739.10.1128/cmr.00011-10: 10.1128/cmr.00011-10
Wu, M.-C., C.-H. Sung, Y.-C. Chang, C.-L. Ho, C.-C. Wu, K.-H. Wu, C.-Y. Lee and K.-D. Yang (2015). "Seroprevalence of Helicobacter pylori and Hepatitis A Virus among Children in Rural Central Taiwan." Japanese Journal of Infectious Diseases 68(6): 494-503.10.7883/yoken.JJID.2014.321: 10.7883/yoken.JJID.2014.321
How to Cite
Yahya, N. (2018). Helicobacter pylori Seropositivity in Children in Duhok City, Iraq. Science Journal of University of Zakho, 6(3), 82-87. https://doi.org/10.25271/sjuoz.2018.6.3.508
Science Journal of University of Zakho