Curative Effects of Ethanol Extract of Prosopis Farcta (Syrian Mesquite) Against Ethylene Glycol Induced Urolithiasis in Male Albino Rats
DOI:
https://doi.org/10.25271/sjuoz.2021.9.2.802Keywords:
Antioxidant activity, cystone, ethylene glycol, kidney stone, Prosopis farctaAbstract
The present study was designed to evaluate the antiurolithiatic activity of Prosopis farcta (P. farcta) ethanol fruit extract in ethylene glycol (EG) induced urolithiasis in male albino rats. Lithiasis was induced by oral administration of EG 1% in male albino rats for 28 days. Seventy eight male albino rats weighing 250-300g were used and divided into six experimental groups. Group A is a control group received standard rat chow and tap water ad libitum, while, rest of groups namely group B, C, D, E, F animals received 1% EG in water for 28 days, then from day 15 to day 28 in addition to EG administration, group C received cystone, group D, E and F received 100, 200 and 300 mg/kg body weight (B.W.) of ethanol fruit extract of P. farcta respectively. On day 28, blood was collected for serum biochemical (serum uric acid, creatinine, urea, electrolytes measurements, malondialdehyde (MDA) and superoxide dismutase (SOD)) determinations. While urine was collected to microscopic analysis of formed crystals besides the kidney weight/ B.W. ratio and B.W. gain/ loss values were determined. Intermediate dose (200mg/kg B.W.) of P. farcta extract significantly decreased serum creatinine, urea, MDA and non-significantly recovered SOD toward control value in group E as compared to group B, also significant elevation in kidney weight/ B.W. ratio and reduction in B.W. gains in group B occurred as compared with group A. In conclusion: P. farcta fruit extract has potentially therapeutic effects on EG induced kidney stone which can be used as effective antiurolithiatic agent rather than cystone.
References
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Ahmed, N. & Sarma, B.P. (2017). A study on the efficacy of Nelumbo nucifera gaertn in the management of Type-2 diabetes mellitus. Journal of Science, 2(3): 10-13.
Aksoy, L. & Aslan, Z. (2017). Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 64(4): 241-248.
Al-Habib, O.A.M., Mahmud, S.A. & Vidari, G. (2015). Anti-Contraction Effects of Euscaphic AcidI solated from Crataegus azarolus var. aronia L on Rat’s Aortic Smooth Muscle. Advances in Life Science and Technology, 33, 48-60.
Al-jeboory, A. & Dizaye, K.F. (2006). Cardiovascular effects of vitexin isolated from Prosopis farcta. Iraqi Journal of Pharmacy, 6(1): 14-19.
Alvi, A.M., Iqbal, N., Bashir, M.A., Rehmani, M.I.A., Ullah, Z. et al. (2018). Efficacy of Rhazya stricta leaf and seed extracts against Rhyzopertha dominica and Trogoderma granarium. Kuwait J. Sci. 45 (3): 64-71.
Arshad, Z., Abrar, A., Nosheen, S. & Mughal, T. (2020). Determining cadmium levels in herbal tooth powders purchased from streetmarkets in Lahore, Pakistan. Kuwait J. Sci., 47 (1): 79-85.
Asadollahi, K., Abassi, N., Afshar, N., Alipour, M. & Asadollahi, P. (2010). Investigation of the effects of Prosopis farcta plant extract on rats aorta. Journal of medicinal plants research, 4(2): 142-147.
Azarfar, A., Rafiee, Z., Ravanshad, Y., Moghadam, N.S. & Bakhtiari, E. (2020). Effect of herbal formulation “cystone®” on urolithiasis. Jundishapur J Nat Pharm Prod., 15(3): e69246.
Bahmani, M., Baharvand-Ahmadi, B., Tajeddini, P., Rafieian-Kopaei, M. & Naghdi, N. (2016). Identification of medicinal plants for the treatment of kidney and urinary stones. Journal of renal injury prevention, 5(3): 129-133.
Byahatti, V.V., Pai, K.V. & D’Souza, M.G. (2010). Effect of phenolic compounds from Bergenia ciliata (Haw.) Sternb. leaves on experimental kidney stones. Ancient science of life, 30(1): 14-17.
Bukhari, I.A., Gilani, A.H., Meo, S.A. & Saeed, A. (2016). Analgesic, anti-inflammatory and anti-platelet activities of Buddleja crispa. BMC Complement. Altern. Med., 16: 79.
Celik, I. & Suzek, H. (2007). Effects of subacute treatment of ethylene glycol on serum marker enzymes and erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. Chemico-biological interactions, 167(2): 145-152.
Cheraft-Bahloul, N., Husson, C., Ourtioualous, M., Sinaeve, S., Atmani, D. et al. (2017). Protective Effects of Pistacia lentiscus L. fruit extract against calcium oxalate monohydrate induced proximal tubular injury. Journal of ethnopharmacology, 209: 248-254.
De Vecchi, A.F., Bamonti, F., Novemberino, C., Ippolito, S., Guerra, L. et al. (2009). Free and total plasma malondialdehyde in chronic renal insufficiency and in dialysis patients. Nephrology Dialysis Transplantation, 24: 2524-2529.
El Menyiy, N., Al Waili, N., Bakour, M., Al-Waili, H. & Lyoussi, B. (2016). Protective effect of propolis in proteinuria, crystaluria, nephrotoxicity and hepatotoxicity induced by ethylene glycol ingestion. Archives of Medical Research, 47(7): 526-534.
Ewais, E.A., Mahgoub, H.A. & Mamdouh, D. (2017). In Vitro Callus Induction in Prosopis farcta (Banks & Sol.) JF Macbr: A Middle East Medicinal Plant, 9: 337-344.
Florens, N., Calzada, C., Lyasko, E., Juillard, L. & Soulage, C.O. (2016). Modified lipids and lipoproteins in chronic kidney disease: a new class of uremic toxins. Toxins, 8(12): 376-402.
Gad, H.A., El-Ahmady, S.H., Abou-Shoer, M.I. & Al-Azizi, M.M. (2013). Application of chemometrics in authentication of herbal medicines: a review. Phytochemical Analysis, 24(1): 1-24.
Karajibani, M., Montazerifar, F. & Feizabad, A.K. (2017). Study of oxidants and antioxidants in addicts. International Journal of High Risk Behaviors and Addiction, 6(2): e35057.
Karimi, E., Aidy, A. & Abbasi, N. (2017). Quantitative HPLC Analysis of Phenolic Compounds in Prosopis Farcta from two Different Ecological Zones of Iran. Chem Technol Ind J, 12(2): 116-124.
Keshavarzi, S., Bahrami, G., Mohammadi, B., Hatami, R. & Miraghaee, S. (2018). Syrian Mesquite extract improves serum lipids and liver tissue in NFALD modelled rabbits. World Family Medicine Journal: Incorporating the Middle East Journal of Family Medicine, 99(5897): 1-8.
Koç, E. R., Ersoy, A., Ilhan, A., Erken, H. A. & Sahın, S. (2015). Is rosuvastatin protective against on noise-induced oxidative stress in rat serum?. Noise & Health, 17(74): 11-16.
Koltuksuz, U., Özen, S., Uz, E., Aydinç, M., Karaman, A. et al. (1999). Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats. Journal of pediatric surgery, 34(10): 1458-1462.
Kuo, H.T., Kuo, M.C., Chiu, Y.W., Chang, J.M., Guh, J.Y. et al. (2005). Increased glomerular and extracellular malondialdehyde levels in patients and rats with focal segmental glomerulosclerosis. European journal of clinical investigation, 35(4): 245-250.
Lim, P.J., Gan, C.S. & Yusof, A. (2019). Lipid lowering effect of Eurycoma longifolia Jack aqueous root extract in hepatocytes. Kuwait J. Sci. 46(2): 52-58.
Luqman, S., Kaushik, S., Srivastava, S., Kumar, R., Bawankule, D. et al. (2009). Protective effect of medicinal plant extracts on biomarkers of oxidative stress in erythrocytes. Pharmaceutical Biology, 47(6): 483-490.
Mahmud, S. A. (2015). Phytochemical screening and anticontractile effect of some active ingriedients of Crataegus azarolus var. aronia on isolated rat’s aorta. Ph.D. thesis. Zakho University. Duhok. Iraq.
Mahmud, S. A., Khdhr, A. R., Taha, A.M., Qadir, H.A., Abdulla, P.M. et al. (2021). Effects of Allium siculum in ethylene glycol induced kidney stone in male albino rats. Kuwait Journal of Science, Accepted.
Manzoor, F., Zafar, A. & Iqbal, I. (2016). Heterotermesindicola (Wasmann) (Isoptera: Rhinotermitidae) responses to extracts from three different plants. Kuwait J. Sci, 43(3): 128-134/
Mohammad, P. Z., Maryam, Sh. F., Jamshidian. A. & Hajinezhad, M. R. (2018). The effect of Syrian mesquite (Prosopis farcta) seed extract on thioacetamide-induced oxidative stress in rats. KAUMS Journal (FEYZ), 22(1): 25-30.
Mutalib, L.Y. (2015). Comparison between phytotherapy and conventional drug therapy used in urolithiasis management in Hawler city, Kurdistan Region\Iraq. Journal of Pharmacognosy and Phytochemistry, 4(1): 83-86.
Nirumand, M., Hajialyani, M., Rahimi, R., Farzaei, M.H., Zingue, S. et. al. (2018). Dietary plants for the prevention and management of kidney stones: preclinical and clinical evidence and molecular mechanisms. International journal of molecular sciences, 19(3): 765-789.
Othman, A, L., Shaswary & AN, I. (2018). Chemical constituents and antibacterial activity of Prosopisfarcta (Fabacea) fruit from Iraq-Kurdistan region. Journal of Duhok University, 21(2): 59-67.
Phillipson, J.D. (2001). Phytochemistry and medicinal plants. Phytochemistry, 56(3): 237-243.
Prabha, D., Mani, P., Malliga, P. & Dahms, H. (2017). Phytochemical and Pharmacological analysis of ethanolic extreact of Prosiois juliflora (SW). World Journal of Pharmacy and Pharmaceutical Sciences, 6(9): 2059-2069.
Sharifi-Rad, J., Kobarfard, F., Ata, A., Ayatollahi, S.A., Khosravi-Dehaghi, N. et al. (2019). Prosopis plant chemical composition and pharmacological attributes. Targeting clinical studies from preclinical evidence. Biomolecules, 9(12): 777-823.
Sharma, I., Khan, W., Parveen, R., Alam, M., Ahmad, I. et al. (2017). Antiurolithiasis activity of bioactivity guided fraction of Bergenia ligulata against ethylene glycol induced renal calculi in rat. BioMed research international, 2017: Article ID 1969525, https://doi.org/10.1155/2017/1969525.
Sud'Ina, G.F., Mirzoeva, O.K., Pushkareva, M.A., Korshunova, G., Sumbatyan, N.V. et al. (1993). Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS letters, 329(1-2): 21-24.
Sundaram, S.S., Suresh, K. & Sundaram, S.P. (2019). Traditional knowledge of medicinal plants used to treat kidney related diseases in selected areas of Madurai district, Tamil Nadu, India. Journal of Medicinal Plants, 7(4): 250-253.
Yagmurca, M., Erdogan, H., Iraz, M., Songur, A., Ucar, M. et al. (2004). Caffeic acid phenethyl ester as a protective agent against doxorubicin nephrotoxicity in rats. Clinica Chimica Acta, 348(1-2): 27-34.
Younis, W., Asif, H., Sharif, A., Riaz, H., Bukhari, I. A. et al. (2018). Traditional medicinal plants used for respiratory disorders in Pakistan. A review of the ethno-medicinal and pharmacological evidence. Chin. Med, 13: 48.
Yuan, H., Ma, Q., Ye, L. & Piao, G. (2016). The traditional medicine and modern medicine from natural products. Molecules, 21(5): 559-577.
Ahmed, N. & Sarma, B.P. (2017). A study on the efficacy of Nelumbo nucifera gaertn in the management of Type-2 diabetes mellitus. Journal of Science, 2(3): 10-13.
Aksoy, L. & Aslan, Z. (2017). Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 64(4): 241-248.
Al-Habib, O.A.M., Mahmud, S.A. & Vidari, G. (2015). Anti-Contraction Effects of Euscaphic AcidI solated from Crataegus azarolus var. aronia L on Rat’s Aortic Smooth Muscle. Advances in Life Science and Technology, 33, 48-60.
Al-jeboory, A. & Dizaye, K.F. (2006). Cardiovascular effects of vitexin isolated from Prosopis farcta. Iraqi Journal of Pharmacy, 6(1): 14-19.
Alvi, A.M., Iqbal, N., Bashir, M.A., Rehmani, M.I.A., Ullah, Z. et al. (2018). Efficacy of Rhazya stricta leaf and seed extracts against Rhyzopertha dominica and Trogoderma granarium. Kuwait J. Sci. 45 (3): 64-71.
Arshad, Z., Abrar, A., Nosheen, S. & Mughal, T. (2020). Determining cadmium levels in herbal tooth powders purchased from streetmarkets in Lahore, Pakistan. Kuwait J. Sci., 47 (1): 79-85.
Asadollahi, K., Abassi, N., Afshar, N., Alipour, M. & Asadollahi, P. (2010). Investigation of the effects of Prosopis farcta plant extract on rats aorta. Journal of medicinal plants research, 4(2): 142-147.
Azarfar, A., Rafiee, Z., Ravanshad, Y., Moghadam, N.S. & Bakhtiari, E. (2020). Effect of herbal formulation “cystone®” on urolithiasis. Jundishapur J Nat Pharm Prod., 15(3): e69246.
Bahmani, M., Baharvand-Ahmadi, B., Tajeddini, P., Rafieian-Kopaei, M. & Naghdi, N. (2016). Identification of medicinal plants for the treatment of kidney and urinary stones. Journal of renal injury prevention, 5(3): 129-133.
Byahatti, V.V., Pai, K.V. & D’Souza, M.G. (2010). Effect of phenolic compounds from Bergenia ciliata (Haw.) Sternb. leaves on experimental kidney stones. Ancient science of life, 30(1): 14-17.
Bukhari, I.A., Gilani, A.H., Meo, S.A. & Saeed, A. (2016). Analgesic, anti-inflammatory and anti-platelet activities of Buddleja crispa. BMC Complement. Altern. Med., 16: 79.
Celik, I. & Suzek, H. (2007). Effects of subacute treatment of ethylene glycol on serum marker enzymes and erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats. Chemico-biological interactions, 167(2): 145-152.
Cheraft-Bahloul, N., Husson, C., Ourtioualous, M., Sinaeve, S., Atmani, D. et al. (2017). Protective Effects of Pistacia lentiscus L. fruit extract against calcium oxalate monohydrate induced proximal tubular injury. Journal of ethnopharmacology, 209: 248-254.
De Vecchi, A.F., Bamonti, F., Novemberino, C., Ippolito, S., Guerra, L. et al. (2009). Free and total plasma malondialdehyde in chronic renal insufficiency and in dialysis patients. Nephrology Dialysis Transplantation, 24: 2524-2529.
El Menyiy, N., Al Waili, N., Bakour, M., Al-Waili, H. & Lyoussi, B. (2016). Protective effect of propolis in proteinuria, crystaluria, nephrotoxicity and hepatotoxicity induced by ethylene glycol ingestion. Archives of Medical Research, 47(7): 526-534.
Ewais, E.A., Mahgoub, H.A. & Mamdouh, D. (2017). In Vitro Callus Induction in Prosopis farcta (Banks & Sol.) JF Macbr: A Middle East Medicinal Plant, 9: 337-344.
Florens, N., Calzada, C., Lyasko, E., Juillard, L. & Soulage, C.O. (2016). Modified lipids and lipoproteins in chronic kidney disease: a new class of uremic toxins. Toxins, 8(12): 376-402.
Gad, H.A., El-Ahmady, S.H., Abou-Shoer, M.I. & Al-Azizi, M.M. (2013). Application of chemometrics in authentication of herbal medicines: a review. Phytochemical Analysis, 24(1): 1-24.
Karajibani, M., Montazerifar, F. & Feizabad, A.K. (2017). Study of oxidants and antioxidants in addicts. International Journal of High Risk Behaviors and Addiction, 6(2): e35057.
Karimi, E., Aidy, A. & Abbasi, N. (2017). Quantitative HPLC Analysis of Phenolic Compounds in Prosopis Farcta from two Different Ecological Zones of Iran. Chem Technol Ind J, 12(2): 116-124.
Keshavarzi, S., Bahrami, G., Mohammadi, B., Hatami, R. & Miraghaee, S. (2018). Syrian Mesquite extract improves serum lipids and liver tissue in NFALD modelled rabbits. World Family Medicine Journal: Incorporating the Middle East Journal of Family Medicine, 99(5897): 1-8.
Koç, E. R., Ersoy, A., Ilhan, A., Erken, H. A. & Sahın, S. (2015). Is rosuvastatin protective against on noise-induced oxidative stress in rat serum?. Noise & Health, 17(74): 11-16.
Koltuksuz, U., Özen, S., Uz, E., Aydinç, M., Karaman, A. et al. (1999). Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats. Journal of pediatric surgery, 34(10): 1458-1462.
Kuo, H.T., Kuo, M.C., Chiu, Y.W., Chang, J.M., Guh, J.Y. et al. (2005). Increased glomerular and extracellular malondialdehyde levels in patients and rats with focal segmental glomerulosclerosis. European journal of clinical investigation, 35(4): 245-250.
Lim, P.J., Gan, C.S. & Yusof, A. (2019). Lipid lowering effect of Eurycoma longifolia Jack aqueous root extract in hepatocytes. Kuwait J. Sci. 46(2): 52-58.
Luqman, S., Kaushik, S., Srivastava, S., Kumar, R., Bawankule, D. et al. (2009). Protective effect of medicinal plant extracts on biomarkers of oxidative stress in erythrocytes. Pharmaceutical Biology, 47(6): 483-490.
Mahmud, S. A. (2015). Phytochemical screening and anticontractile effect of some active ingriedients of Crataegus azarolus var. aronia on isolated rat’s aorta. Ph.D. thesis. Zakho University. Duhok. Iraq.
Mahmud, S. A., Khdhr, A. R., Taha, A.M., Qadir, H.A., Abdulla, P.M. et al. (2021). Effects of Allium siculum in ethylene glycol induced kidney stone in male albino rats. Kuwait Journal of Science, Accepted.
Manzoor, F., Zafar, A. & Iqbal, I. (2016). Heterotermesindicola (Wasmann) (Isoptera: Rhinotermitidae) responses to extracts from three different plants. Kuwait J. Sci, 43(3): 128-134/
Mohammad, P. Z., Maryam, Sh. F., Jamshidian. A. & Hajinezhad, M. R. (2018). The effect of Syrian mesquite (Prosopis farcta) seed extract on thioacetamide-induced oxidative stress in rats. KAUMS Journal (FEYZ), 22(1): 25-30.
Mutalib, L.Y. (2015). Comparison between phytotherapy and conventional drug therapy used in urolithiasis management in Hawler city, Kurdistan Region\Iraq. Journal of Pharmacognosy and Phytochemistry, 4(1): 83-86.
Nirumand, M., Hajialyani, M., Rahimi, R., Farzaei, M.H., Zingue, S. et. al. (2018). Dietary plants for the prevention and management of kidney stones: preclinical and clinical evidence and molecular mechanisms. International journal of molecular sciences, 19(3): 765-789.
Othman, A, L., Shaswary & AN, I. (2018). Chemical constituents and antibacterial activity of Prosopisfarcta (Fabacea) fruit from Iraq-Kurdistan region. Journal of Duhok University, 21(2): 59-67.
Phillipson, J.D. (2001). Phytochemistry and medicinal plants. Phytochemistry, 56(3): 237-243.
Prabha, D., Mani, P., Malliga, P. & Dahms, H. (2017). Phytochemical and Pharmacological analysis of ethanolic extreact of Prosiois juliflora (SW). World Journal of Pharmacy and Pharmaceutical Sciences, 6(9): 2059-2069.
Sharifi-Rad, J., Kobarfard, F., Ata, A., Ayatollahi, S.A., Khosravi-Dehaghi, N. et al. (2019). Prosopis plant chemical composition and pharmacological attributes. Targeting clinical studies from preclinical evidence. Biomolecules, 9(12): 777-823.
Sharma, I., Khan, W., Parveen, R., Alam, M., Ahmad, I. et al. (2017). Antiurolithiasis activity of bioactivity guided fraction of Bergenia ligulata against ethylene glycol induced renal calculi in rat. BioMed research international, 2017: Article ID 1969525, https://doi.org/10.1155/2017/1969525.
Sud'Ina, G.F., Mirzoeva, O.K., Pushkareva, M.A., Korshunova, G., Sumbatyan, N.V. et al. (1993). Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS letters, 329(1-2): 21-24.
Sundaram, S.S., Suresh, K. & Sundaram, S.P. (2019). Traditional knowledge of medicinal plants used to treat kidney related diseases in selected areas of Madurai district, Tamil Nadu, India. Journal of Medicinal Plants, 7(4): 250-253.
Yagmurca, M., Erdogan, H., Iraz, M., Songur, A., Ucar, M. et al. (2004). Caffeic acid phenethyl ester as a protective agent against doxorubicin nephrotoxicity in rats. Clinica Chimica Acta, 348(1-2): 27-34.
Younis, W., Asif, H., Sharif, A., Riaz, H., Bukhari, I. A. et al. (2018). Traditional medicinal plants used for respiratory disorders in Pakistan. A review of the ethno-medicinal and pharmacological evidence. Chin. Med, 13: 48.
Yuan, H., Ma, Q., Ye, L. & Piao, G. (2016). The traditional medicine and modern medicine from natural products. Molecules, 21(5): 559-577.
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2021-06-30
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Ahmed, K. M., & Mahmud, S. A. (2021). Curative Effects of Ethanol Extract of Prosopis Farcta (Syrian Mesquite) Against Ethylene Glycol Induced Urolithiasis in Male Albino Rats. Science Journal of University of Zakho, 9(2), 89–96. https://doi.org/10.25271/sjuoz.2021.9.2.802
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